WZB117
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- CAS-Nr.
- 1223397-11-2
- Englisch Name:
- WZB117
- Synonyma:
- WZB-117;CS-2648;WZB-117 >=98% (HPLC);WZB117, 10 mM in DMSO;WZB117;WZB-117;WZB 117;Glucose Transporter Inhibitor IV, WZB117;3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate);3-Hydroxy-benzoic acid 1,1′-(3-fluoro-1,2-phenylene) ester;Benzoic acid, 3-hydroxy-, 1,1'-(3-fluoro-1,2-phenylene) ester;3-hydroxybenzenemacetic acid1,1'-(3-fluoro-1,2-isophenyl)ester
- CBNumber:
- CB52750588
- Summenformel:
- C20H13FO6
- Molgewicht:
- 368.31
- MOL-Datei:
- 1223397-11-2.mol
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WZB117 Eigenschaften
- Siedepunkt:
- 628.4±55.0 °C(Predicted)
- Dichte
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble20mg/mL, clear
- pka
- 8.96±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may br stored at -20° for up to 2 months.
- InChI
- 1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H
- InChIKey
- FRSWCCBXIHFKKY-UHFFFAOYSA-N
- SMILES
- O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O
WZB117 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
WZB 117 is a GLUT1 inhibitor.
Allgemeine Beschreibung
A
bis-hydroxybenzoate compound that acts as a fast-acting, irreversible blocker of glucose transport by GLUT1 in red blood cells. Shown to rapidly inhibit glucose transport in cancer cells (IC
50 ~ 500 nM in A549 cells) and block proliferation. Its inhibitory effects are more pronounced in hypoxic cancer cells. It binds directly to GLUT1 involving three hydrogen bonds, one each with Asn
34, Arg
126, and Trp
412. Also shown to reduce the levels of GLUT1 protein, intracellular ATP levels, and glycolytic enzymes and increase the level of AMPK in tumor cells. Preferentially induces cell cycle arrest and causes senescence and necrosis in red blood cells and tumor cells (IC
50 = 10 μM) over non cancerous cells and synergizes the anti-tumor effects of cisplatin (Cat. No. 232120) and paclitaxel (Cat. No. 580555). Also, effectively suppresses tumor growth in human A549 lung cancer grafted nude mice model (10 mg/kg, i.p., daily).
Biochem/physiol Actions
Cell permeable: yes
WZB117 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
WZB117 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 115)Lieferanten
- 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
- 3-Hydroxy-benzoic acid 1,1′-(3-fluoro-1,2-phenylene) ester
- Glucose Transporter Inhibitor IV, WZB117
- CS-2648
- WZB117;WZB-117;WZB 117
- Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
- Benzoic acid, 3-hydroxy-, 1,1'-(3-fluoro-1,2-phenylene) ester
- WZB-117 >=98% (HPLC)
- WZB117, 10 mM in DMSO
- 3-hydroxybenzenemacetic acid1,1'-(3-fluoro-1,2-isophenyl)ester
- WZB-117
- 1223397-11-2
- API
