6-ForMylindolo[3,2-b]carbazole
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- CAS-Nr.
- 172922-91-7
- Englisch Name:
- 6-ForMylindolo[3,2-b]carbazole
- Synonyma:
- FICZ;FICZ, 10 mM in DMSO;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ
- CBNumber:
- CB5312397
- Summenformel:
- C19H12N2O
- Molgewicht:
- 284.31
- MOL-Datei:
- 172922-91-7.mol
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6-ForMylindolo[3,2-b]carbazole Eigenschaften
- Siedepunkt:
- 630.3±35.0 °C(Predicted)
- Dichte
- 1.463±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 10 mg/ml).
- pka
- 15.66±0.30(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow to orange
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
- InChIKey
- ZUDXFBWDXVNRKF-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C2=C1C(C=O)=C1C3=C(NC1=C2)C=CC=C3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
1 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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6-ForMylindolo[3,2-b]carbazole Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
6-ForMylindolo[3,2-b]carbazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-ForMylindolo[3,2-b]carbazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 127)Lieferanten
- 6-FORMYLINDOLO [3,2-B] CARBAZOLE
- Indolo[3,2-b]carbazole-6-carbaldehyde
- 5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde
- 5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde
- 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
- 6-FORMYLINDOLO A CARBAZOLE
- Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
- 6-Formylindolo[3,2-b]carbazole (FICZ)
- inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ
- 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand
- FICZ, 10 mM in DMSO
- FICZ
- 172922-91-7
- C19H10N2O
