1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion
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- CAS-Nr.
- 70356-09-1
- Bezeichnung:
- 1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion
- Englisch Name:
- Avobenzone
- Synonyma:
- PARSOL 1789;AVB;Butylmethoxydibenzoylmethane;1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione;Avobenzon;Eusolex 9020;UV Absorber 1789;1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione,Avobenzone, Butyl methoxydibenzoylmethane;AVO;Pars
- CBNumber:
- CB5337318
- Summenformel:
- C20H22O3
- Molgewicht:
- 310.39
- MOL-Datei:
- 70356-09-1.mol
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1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion Eigenschaften
- Schmelzpunkt:
- 81-84 °C
- Siedepunkt:
- 463.6±35.0 °C(Predicted)
- Dichte
- 1.079
- Dampfdruck
- 0Pa at 25℃
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- pka
- 9.74±0.13(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- Wasserl?slichkeit
- 27μg/L at 20℃
- maximale Wellenl?nge (λmax)
- 356nm(EtOH)(lit.)
- Merck
- 14,888
- Henry's Law Constant
- 4.9×104 mol/(m3Pa) at 25℃, HSDB (2015)
- Major Application
- cleaning products
cosmetics
environmental
food and beverages
personal care
- Kosmetik-Inhaltsstoffe Funktionen
- LIGHT STABILIZER
UV ABSORBER
UV FILTER
- InChI
- 1S/C20H22O3/c1-20(2,3)16-9-5-14(6-10-16)18(21)13-19(22)15-7-11-17(23-4)12-8-15/h5-12H,13H2,1-4H3
- InChIKey
- GTIRDWBOUTYFQO-UHFFFAOYSA-N
- SMILES
- COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C
- LogP
- 6.1 at 20℃
- CAS Datenbank
- 70356-09-1(CAS DataBase Reference)
- EPA chemische Informationen
- 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)- (70356-09-1)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50/53 |
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| S-S?tze: |
60-61 |
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| RIDADR |
UN3077 9/PG 3 |
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| WGK Germany |
2 |
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| TSCA |
TSCA listed |
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| HS Code |
29145000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Chronic 4 |
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| Giftige Stoffe Daten |
70356-09-1(Hazardous Substances Data) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Avobenzone is a full-spectrum ultraviolet A (UVA) blocker. It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC
30s = 21.94 and 24.25 μM, respectively). Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2''-deoxyguanosine (8-OH-dG; ), as well as inhibits UVA-induced depletion of glutathione (GSH; ), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM. Formulations containing avobenzone have been used as a sun protectant in sunscreen products.
Verwenden
avobenzone (BMDM, butyl methoxydibenzoylmethane) is a sun-A screen chemical that offers broad-range protection against uVA rays. It is associated with some photoinstability, which can be overcome in the overall sunscreen formulation. It is approved for use up to 3 percent in the united States and 5 percent in the european union. Avobenzone is noted to rarely be photosensitizing.
Allgemeine Beschreibung
Avobenzone is an UVA filter. It is used in sunscreen lotions and cosmetic formulations. It has maximum absorption at ca 340–350 nm, decreasing under UV irradiation resulting in loss of the UVA protecting effect. Its photostability is very sensitive as it is stable in polar protic solvent and is photolabile in nonpolar solvents.
1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 621)Lieferanten
70356-09-1(1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propan-1,3-dion)Verwandte Suche:
- AVOBENZONE
- EUSOLEX(R) 9020
- 4-tert-butyl-4'-methoxy-dibenzoylmethane
- 4-T-BUTYL-4'-METHOXY-DIBENZOYLMETHANE
- 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione
- 1-(4-TERT-BUTYLPHENYL)-3-(4-METHOXYPHENYL) 1,3-PROPANEDIOL
- 1-(P-T-BUTYLPHENYL)-3-(P-METHOXYPHENYL)-1,3-PROPANEDIONE
- 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-3-propanedione
- 1-[4-(1,2-Dimethylethyl)phenyl]-3-(4-methoxyphenyl-1,3-propanedione
- Avobenzone (500 mg)
- Avobenzone (500 mg)G1E1090.996mg/mg(dr)
- Escalol 517
- CAPITAL SOLEIL 15 (avobenzone
- Methoxyphenyl)-3-(4-tert-butylphenyl)-1
- Avobenzone (Parsol 1789)
- 1-(4-tert-butylphenyl)-3-(4-Methoxyphenyl)propane-1,3-diol
- p-tert-Butyl-p-Methoxy dibenzoyl Methane
- Pars
- Butyl MethoxydibenzoylMethane/Avobenzone
- 1- (4-tert-butylphenyl) -3- (4-Methoxyphenyl) propan-1,3-dione
- Avobenzone SynonyMs 4-tert-Butyl-4'-Methoxy-dibenzoylMethane
- Parsol 1789 0
- Avobenzon ,Parsol 1789
- BF2AVB
- 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione
- Butyl methoxydibenzoylmethane Solution, 100ppm
- 1-(4-Methoxyphenyl)-3-(4-Tert-Butylphenyl)Propan-1,3-Dione
- EUSOLEX 9020 95- 105%
- 1-(4-TERT-BUTYLPHENYL)-3-(4-METHOXYPHENYL)-PROPANE-1,3-DIONE [AVOBENZONE]
- Avobenzone(USP)
- Butyl-methoxydibenzoylmethane (B-MDM). Sunblock, Parsol1789
- 1-(4-TERT-BUTYLPHENYL)-3-(4-METHOXYPHENYL)-1,3-PROPANDIONE
- 4-TERT-BUTYLMETHOXYDIBENZOYLMETHANE
- TERT-BUTYLMETHOXYDIBENZOYLMETHANE
- AVOBENZONE / BUTYLMETHOXYDIBENZOYLMETHANE
- AVOBENZNOE
- Parseal-1789
- 4-TERT-BUTYL-4''-METHOXYDIBENZOYLMETHANE (AVOBENZONE)
- p-t-Butyl p-Methoxydibenzoymethane
- 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione
- 4-Methoxy-4'-tert-butyldibenzoylmethane
- Pasol1789
- 1-(p-tert-Butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione
- 1-[4-(tert-Butyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione
- P-1789
- Parsol A
- Avobenzone (>=98%)
- 2-(4-tert-Butylbenzoyl)-4'-methoxyacetophenone
- LGB-AVB
- UV Avobenzone
- Avobenzone Basic information
- Parsol 1789 (1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propandion)
- 1-(4-TERT-BUTYLPHENYL)-3-(4-METHOXYPHENYL) 1,3-PROPA
- 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione >
- Butyl-methoxydibenzoylmethane (B-MDM). Sunblock, Parsol1789@100 μg/mL in MeOH
- AVO
- Butyl methoxydibenzoylmethane Solution in Methanol/THF/Water, 1000μg/mL
- 1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione (UV 1789)
