RYCMAAFECCXGHI-ILKKLZGPSA-N Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
N5-(1-Iminoethyl)-L-ornithine Dihydrochloride is an inhibitor of nitric oxide synthase (NOS), an enzyme that catalyzes the conversion of L-arginine to L-citrulline and nitric oxide. It also improves cardiac function and microcirculation. N5-(1-Iminoethyl)-L-ornithine Dihydrochloride inhibits inducible NOS (iNOS). These enzymes play critical roles in a wide array of physiological and pathophysiological conditions such as blood pressure regulation, inflammation, and infection.
Allgemeine Beschreibung
Cell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC
50 = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC
50 = 2 μM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC
50 = 19.5 mg/kg).
Biochem/physiol Actions
Cell permeable: yes
RYCMAAFECCXGHI-ILKKLZGPSA-N Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
