(S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid
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- CAS-Nr.
- 60166-93-0
- Bezeichnung:
- (S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid
- Englisch Name:
- Iopamidol
- Synonyma:
- isovue;niopam;b-15000;lamide);sq13396;Iopanol;iopamiro;Jopamiro;Solutras;iopamido
- CBNumber:
- CB5384796
- Summenformel:
- C17H22I3N3O8
- Molgewicht:
- 777.09
- MOL-Datei:
- 60166-93-0.mol
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(S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid Eigenschaften
- Schmelzpunkt:
- >3200C (dec)
- alpha
- D20 -2.01° (c = 10 in water)
- Siedepunkt:
- 740.14°C (rough estimate)
- Dichte
- 2.0203 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- Freely soluble in water, very slightly soluble in methanol, practically insoluble in ethanol (96 per cent) and in methylene chloride
- Aggregatzustand
- Solid
- pka
- pKa (25°) 10.70
- Farbe
- White to off-white
- Wasserl?slichkeit
- 473.7g/L(25 ºC)
- Henry's Law Constant
- 9.0×1019 mol/(m3Pa) at 25℃, HSDB (2015)
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- XQZXYNRDCRIARQ-LURJTMIESA-N
- SMILES
- C1(C(NC(CO)CO)=O)=C(I)C(NC(=O)[C@@H](O)C)=C(I)C(C(NC(CO)CO)=O)=C1I
- CAS Datenbank
- 60166-93-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 1 |
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| HS Code |
2924296000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Giftige Stoffe Daten |
60166-93-0(Hazardous Substances Data) |
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| Toxizit?t |
LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder); LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre). |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Crystalline Powder
Verwenden
Iopamidol is an organic iodine compound and used as a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium). Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05)
Definition
ChEBI: Iopamidol is a benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is a benzenedicarboxamide, an organoiodine compound and a pentol.
Allgemeine Beschreibung
Iopamidol is a low-osmolar, nonionicmonomer with 49% organically bound iodine. It is indicatedfor use in angiography, excretory urography, andnumerous CT procedures.
Nebenwirkungen
Arm, back, or jaw pain; blurred vision; chest pain or discomfort; chest tightness or heaviness; confusion; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; fast or irregular heartbeat; feeling of warmth; hives; lightheadedness, dizziness, or fainting; nausea; redness of the face, neck, arms, and occasionally, upper chest; slow or irregular heartbeat; sudden sweating; trouble breathing; unusual tiredness or weakness
Mode of action
Iopamidol is a Radiographic Contrast Agent. The mechanism of action of iopamidol is as a X-Ray Contrast Activity.
(S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Thionyldichlorid
1,3-Propanediol, 2-(2,2-diethoxyethyl)-,monoacetate,(R)-
1,3,4-Thiadiazol-2-amin
5-Amino-2,4,6-triiodisophthalsure
5-amino-N1,N3-bis(1,3-dihydroxypropan-2-yl)isophthalamide
5-Amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl) ethyl]-2,4,6-triiodobenzene-1,3-dicarboxamide
(S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
2-Aminopropan-1,3-diol
5-Nitroisophthalsure
Downstream Produkte
(S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 228)Lieferanten
60166-93-0((S)-N,N'-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodisophthaldiamid)Verwandte Suche:
- N,N'-Bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-Benzenedicarboxamide
- N,N'-BIS(1,3-DIHYDROXYPROPAN-2-YL)-5-(2-HYDROXYPROPANOYLAMINO)-2,4,6-TRIIODO-BENZENE-1,3-DICARBOXAMIDE
- 1,3-benzenedicarboxamide,n,n’-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydr
- -2-propylamide)
- 6-triiodo-(s)-oxy-1-oxopropyl)amino)-
- b-15000
- hthalamide
- iopamiro
- iopamiron
- isovue
- isovue-370
- jopamiron200
- l-(+)-n,n’-bis(2-hydroxy-1-hydroxymethylethyl)-2,4,6-triiodo-5-lactamideisop
- l-5alpha-hydroxypropionylamino-2,4,6-triiodoisophthalicaciddi(1,3-dihydroxy
- l-5alpha-idrossipropionilamino-2,4,6-triiodoisoftal-di(1,3-diidrossi-2-propi
- lamide)
- niopam
- niopam300
- solutrast
- solutrast370
- sq13396
- (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodoisophthaldiamide
- Iomapidol
- Jopamiro
- N,NBis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
- Solutras
- 1,3-Benzenedicarboxamide, N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-, (S)-
- 1,3-Benzenedicarboxamide, N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-
- Iopamidol 300
- Iopamiro 370
- Iopamiron 300
- Iopamiron 370
- Isovue 300
- (S)-N,N'-Bis(1,3-dihydroxypropan-2-yl)-5-[[(2S)-2-hydroxypropanoyl]amino]-2,4,6-triiodobenzene-1,3-dicarboxamide
- Iopamidol (200 mg)
- (S)-N,N′-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-5-lactamidoisophthalamide
- Iopamidol ( for Contrast Agents )
- IOPAMIRO;ISOVUE;IOPAMIRON;NIOPAM
- (2S)-Iopamidol, isomer mixture
- 1,3-Benzenedicarboxamide, N1,N3-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-
- (S)-N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanamido)-2,4,6-triiodoisophthalamide
- Iopamidol USP/EP/BP
- iopamido
- (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy...
- Iopamidol (1344702)
- Iopomidol
- Iopamidol
- IPAMIDOL
- (2S)-Iopamidol in methanol
- C14348400 Iopamidol
- Iopanol
- Iopamidol, 10 mM in DMSO
- Iopamidol,99%
- 60166-93-0
- 37438-68-8
- 77709
- Diagnostic
- Intermediates & Fine Chemicals
