2-Methylbenzimidazol
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- CAS-Nr.
- 615-15-6
- Bezeichnung:
- 2-Methylbenzimidazol
- Englisch Name:
- 2-Methylbenzimidazole
- Synonyma:
- 2-METHYL-1H-BENZO[D]IMIDAZOLE;2-methyl-benzimidazol;1H-Benzimidazole, 2-methyl-;MethylbenziMidazole;AKOS 90363;RARECHEM AQ NN 0067;2-METHYLENZIMIDAZOLE;2-METHYLBENZIMIDAZOLE;Methyl-2-benzimidazole;1H-2-Methylbenzimidazol
- CBNumber:
- CB5439553
- Summenformel:
- C8H8N2
- Molgewicht:
- 132.16
- MOL-Datei:
- 615-15-6.mol
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2-Methylbenzimidazol Eigenschaften
- Schmelzpunkt:
- 175-177 °C (lit.)
- Siedepunkt:
- 234.08°C (rough estimate)
- Dichte
- 1.1083 (rough estimate)
- Brechungsindex
- 1.6013 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Crystalline Powder
- pka
- 6.19(at 25℃)
- Farbe
- Light beige to brown
- Wasserl?slichkeit
- slightly soluble
- BRN
- 112264
- InChI
- 1S/C8H8N2/c1-6-9-7-4-2-3-5-8(7)10-6/h2-5H,1H3,(H,9,10)
- InChIKey
- LDZYRENCLPUXAX-UHFFFAOYSA-N
- SMILES
- Cc1nc2ccccc2[nH]1
- CAS Datenbank
- 615-15-6(CAS DataBase Reference)
- NIST chemische Informationen
- 1H-benzimidazole, 2-methyl-(615-15-6)
- EPA chemische Informationen
- 1H-Benzimidazole, 2-methyl- (615-15-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-37/38-41-20/21/22 |
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| S-S?tze: |
26-39-45-44 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DD9100000 |
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| TSCA |
TSCA listed |
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| HS Code |
29339990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
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2-Methylbenzimidazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
light beige to brown crystalline powder. Soluble in alcohol, ether, hot water and sodium hydroxide solution, insoluble in benzene.
Verwenden
- 2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents.
- It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones.
- It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals.
- 2-Methylbenzimidazole also exhibits corrosion inhibition.
synthetische
2-Methylbenzimidazole is synthesized by the condensation of o-phenylenediamine with acetic acid. The mixture of o-phenylenediamine and acetic acid is heated at 100°C for 2 hours and then cooled slowly. 10% sodium hydroxide solution is added slowly to the mixture until it is slightly alkaline. The mixture is filtered and washed with cold water. The crude product is then recrystallized with water and decolorized with activated charcoal to obtain the final product. The yield is 68%.
Sicherheitsprofil
Poison by intravenous
route. Moderately toxic by ingestion.
Experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx.
Synthese
o-phenylenediamine and glacial acetic acid as raw materials undergo a condensation reaction in the presence of toluene as a solvent under the conditions of heating reflux to produce 2-methylbenzimidazole. The specific procedure is as follows: Add o-phenylenediamine and acetic acid to toluene, stir thoroughly, reflux for 2 to 12 hours, then cool directly and slowly to 0–30°C for crystallisation. Stir the crystallisation mixture for 0.5 to 12 hours, then pump and filter. Wash the solid with toluene, recover the toluene, and dry under reduced pressure to obtain the white solid powder 2-methylbenzimidazole.
2-Methylbenzimidazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Methylbenzimidazol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 384)Lieferanten
615-15-6(2-Methylbenzimidazol)Verwandte Suche:
- 2-METHYL-1H-BENZIMIDAZOLE
- 2-METHYLBENZIMIDAZOLE
- AKOS 90363
- 1H-2-Methylbenzimidazol
- 1H-2-Methylbenzimidazole
- 2-methyl-1h-benzimidazol
- Acetamidine, N-N'-o-phenylene-
- Benzimidazole, 2-methyl-
- Methyl-2-benzimidazole
- n-n’-o-phenylene-acetamidin
- RARECHEM AQ NN 0067
- 2-METHYLENZIMIDAZOLE
- 2-Methylbenzimidazole,98%
- 1H-Benzimidazole,2-methyl-(9CI)
- 2-Methyl-1,3-benzodiazde
- 2-Methyl-1H-benzoimidazole
- 2-Methyl-1,3-benzodiazole
- 2-Methylbenzimidazole Vetec(TM) reagent grade, 98%
- 2-Methylbenzimidazole>
- 2-methyl-benzimidazol
- MethylbenziMidazole
- 1-Butanone,1-(4-bromophenyl)-9-chloro-
- Boronicacid,B-(1,6-dihydro-6-oxo-7-pyridinyl)-
- 2-Methylbenzimidazole，99%
- 2-Methylbenzo[d]imidazole
- 1H-Benzimidazole, 2-methyl-
- 2-METHYL-1H-BENZO[D]IMIDAZOLE
- 615-15-6
- 616-15-6
- 615-16-6
- 615-51-6
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