4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
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4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat Eigenschaften
- Schmelzpunkt:
- 192 C
- storage temp.
- 2-8°C
- L?slichkeit
- Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile.
- Aggregatzustand
- Solid
- Farbe
- White to Pale Beige
- PH
- pH (10g/l, 25℃) : 3.0~4.0
- Wasserl?slichkeit
- Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
- maximale Wellenl?nge (λmax)
- 297nm(MeOH)(lit.)
- Merck
- 14,5307
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- YNQQEYBLVYAWNX-WLHGVMLRSA-N
- SMILES
- C1(=C2/CCN(C)CC/2)\C2=C(C=CC=C2)CC(=O)C2SC=CC\1=2.C(/C(=O)O)=C\C(=O)O
- CAS Datenbank
- 34580-14-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher | Xn,T | ||
|---|---|---|---|
| R-S?tze: | 22-36/37/38-23/24/25 | ||
| S-S?tze: | 36-45-36/37/39-26 | ||
| WGK Germany | 3 | ||
| RTECS-Nr. | DE8260000 | ||
| HS Code | 29349990 | ||
| Speicherklasse | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
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| Toxizit?t | child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992. |
| Bildanzeige (GHS) |
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4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Ketotifen is a histamine H1 receptor antagonist (Ki = 1.3 nM) and mast cell stabilizer. It is selective for H1 receptors over H2 and H3 receptors (Kis = 987 and 2,500 nM, respectively). Ketotifen (50 and 100 μM) inhibits degranulation of rat peritoneal mast cells induced by compound 48/80 . It inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats by 54.6% when administered orally at a dose of 20 mg/kg. Ketotifen (30 mg/kg) inhibits the quick phase airway response in a rat ovalbumin-induced immediate airway response model. Formulations containing ketotifen have been used in the treatment of itching associated with allergic conjunctivitis.Chemische Eigenschaften
Off-White SolidVerwenden
Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking waterAllgemeine Beschreibung
Ketotifen fumarate, 4-(1-methyl-4-piperidylidene)-4Hbenzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogenfumarate (Zaditor), is a fine crystalline powder.Ketotifen is a ketothiophene isostere analog of the dibenzocycloheptaneantihistamines. The solution contains0.345 mg of ketotifen fumarate, which is equivalent to0.25 mg of ketotifen. The solution also contains the preservativebenzalkonium chloride (0.01%) as well as glycerol,sodium hydroxide and/or hydrochloric acid (to adjust pH),and purified water. It has a pH of 4.4 to 5.8 and an osmolalityof 210 to 300 mOsm/kg.The recommended dose of ketotifen solution is 1 drop instilledinto each affected eye every 8 to 12 hours. The mostfrequently reported adverse reactions are conjunctival infection,headaches, and rhinitis. This drug product is for ocularadministration only and not for injection or oral use.Ketotifen solution should be used with caution during pregnancyor while nursing, because its safety has not been studiedunder these circumstances.
Biologische Aktivit?t
An H 1 receptor antagonist.4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 505)Lieferanten
| Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20122 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 |
sales@sjar-tech.com | China | 529 | 58 |
| Shandong Xuhuang New material CoLTD | +86-15095020839 +86-17660422208 |
China | 726 | 58 | |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29815 | 58 |
| QINGDAO HONG JIN CHEMCIAL CO.,LTD. | +86-86-532-83657313 +86-18663969289 |
hjt@hong-jin.com | China | 225 | 58 |
34580-14-8(4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat)Verwandte Suche:
Methylacrylat
Kresoxim-methyl
Eisen(II)fumarat
Methyl-4-hydroxybenzoat
Bensulfuron methyl
2,2,6,6-Tetramethyl-4-piperidylamin
Ketotifen
2-Benzothienylboronic acid
Dimethylfumarat
Fumarsure
Thiophanat-methyl
2,2,6,6-Tetramethylpiperidin-4-ol
Methyl
1-(2-Thienyl)propan-1-on
Pizotifen
1-(3-Methyl-2-thienyl)ethan-1-on
Parathion-methyl (ISO)
Brommethan
- Allerkif
- Anatifen
- Ketotifen Hydrogen FuMarate, EP
- 4-(1-Methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fuMarate
- 4,9-Dihydro-4-(1-Methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-2-Butenedioate
- Totifen
- Zasten
- Ketotifen FuMarate API
- 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one,(2E)-2-butenedioate (1:1)
- Ketotifen for peak identification
- 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe
- hc20-511fumarate
- 4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate
- 4,9-DIHYDRO-4-(1-METHYL-4-PIPERIDINYLIDENE-10H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHEN-10-ONE) FUMARATE
- (E)-but-2-enedioic acid,10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
- KETOTIFEN FUMARATE
- KETOTIFEN FUMARATE SALT
- 4,9-dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one fumarate
- 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
- Ketotifen fumarate salt, 99%, a second-generation noncompetitive H1-antihistamine and mast cell stabilizer
- Ketotifen hydrogen fumarate CRS
- KetotifenFumarate>
- Ketotifen fumarate USP/EP/BP
- Ketotifen Fumarate (HC 20511)
- Ketotifen fumarateQ: What is Ketotifen fumarate Q: What is the CAS Number of Ketotifen fumarate Q: What is the storage condition of Ketotifen fumarate Q: What are the applications of Ketotifen fumarate
- Ketotifene fumarate
- 10H-Benzo4,5cyclohepta1,2-bthiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1)
- zaditor
- 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
- 4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one hydrogen (E)-butenedioate
- zaditen
- Ketotifen fumerate
- Ketotifen fumarate (Zaditor)
- Ketotiphen
- Ketotifen fumarate in methanol
- Ketotifen fumarate, H1 antagonist
- Ketotifen fumarate, 10 mM in DMSO
- Ketotifen Hydrogen Fumarate 1.0 mg/ml in Methanol (as free base)
- Ketotifen fumarate (Standard)
- KETOTIFEN FUMARATE EP
- ketotifen fuMarat
- 34580-14-8
- 34580-14-7
- C19H19NOSC4H4O4C23H23
- C19H19NOSC4H4O4C23H23NO5S
- C19H19NOSC4H4O4
- H1 histamine receptor antagonist.
- Antagonists
- Histaminergics
- Neurotransmitters
- Histamine receptor
- Antiallergic agents
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Pharmaceutical raw material




