Pemigatinib
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- CAS-Nr.
- 1513857-77-6
- Englisch Name:
- Pemigatinib
- Synonyma:
- IBI-375;INCB54828;INCB 54828;INCB-54828;INCB-054828;Pemigatinib;2H8]-Pemigatinib;INCB-054828 (Pemigatinib);Pemigatinib, 10 mM in DMSO;Terbufos Impurity 14 (Ethion)
- CBNumber:
- CB54796678
- Summenformel:
- C24H27F2N5O4
- Molgewicht:
- 487.5
- MOL-Datei:
- 1513857-77-6.mol
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Pemigatinib Eigenschaften
- Siedepunkt:
- 697.6±55.0 °C(Predicted)
- Dichte
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- pka
- 11.56±0.40(Predicted)
- Farbe
- White to light yellow
- InChIKey
- HCDMJFOHIXMBOV-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C2=C(F)C(OC)=CC(OC)=C2F)CC2=CN=C3NC(CN4CCOCC4)=CC3=C2N1CC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Pemigatinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.
Trademarks
Pemazyre
Synthese
Removal of the acetaldehyde protecting group in compound 284 under acidic conditions afforded aldehyde 285. Reductive amination of aldehyde 285 with aniline 286 gave benzylamine 287. Benzylamine 287 reacted with isocyanate 288 to form the desired urea 289. In the presence of a strong base, LHMDS (lithium dimethylsilane), compound 289 underwent intramolecular cyclization to displace the adjacent chlorine atom to yield azatricyclic compound 290. Conventional hydrolysis to remove the benzenesulfonyl group completed the construction of pemitinib, affording the final product in good yield.
IC 50
FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM
Pemigatinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-7-(phenylsulfonyl)-
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-7-(phenylsulfonyl)-
1H-Pyrrolo[2,3-b]pyridine-5-methanamine, N-(2,6-difluoro-3,5-dimethoxyphenyl)-4-(ethylamino)-
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-
4-(ethylamino)-1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde
4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE
Downstream Produkte
Pemigatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 142)Lieferanten
- Pemigatinib
- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- INCB-054828
- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-
- IBI-375
- 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- 2H8]-Pemigatinib
- INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic
- INCB 54828
- INCB54828
- INCB-54828
- Terbufos Impurity 14 (Ethion)
- Pemigatinib, 10 mM in DMSO
- 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- 11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one
- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-3,4-dihydro-1H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2(7H)-one
- INCB-054828 (Pemigatinib)
- 1513857-77-6
- 1513857-77-7
- C24H27F2N5O4
- APIS
