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Pomalidomide-PEG4-CO2H

Pomalidomide-PEG4-CO2H Struktur
2138440-81-8
CAS-Nr.
2138440-81-8
Englisch Name:
Pomalidomide-PEG4-CO2H
Synonyma:
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;amine-tetrapolyethyldiol-carboxylic acid;Pomalidomide-PEG4-CO2H;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
CBNumber:
CB54846410
Summenformel:
C24H31N3O10
Molgewicht:
521.52
MOL-Datei:
2138440-81-8.mol

Pomalidomide-PEG4-CO2H Eigenschaften

Siedepunkt:
773.6±60.0 °C(Predicted)
Dichte
1.385±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.28±0.10(Predicted)
Aggregatzustand
Viscous Liquid
Farbe
Light yellow to yellow
InChIKey
CAANPUBZFFRWQP-UHFFFAOYSA-N
SMILES
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCC(O)=O)=O)NC1=O

Sicherheit

WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids

Pomalidomide-PEG4-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

Pomalidomide-PEG4-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pomalidomide-PEG4-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 39)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8615965530500
nickzhang@hangyubiotech.com China 9949 58
HANGZHOU LEAP CHEM CO., LTD.
+86-571-87711850
market18@leapchem.com China 43333 58
Xian confluore Biological Technology Co., Ltd.
+86-15680926068
1924344760@confluore.cn China 2997 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
ChemShuttle, Inc. 0510-83588313-811 18800520310
sales@chemshuttle.com China 2999 62
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
3008007409@qq.com China 89686 60
Aikon International Limited 025-58851090 15955137747
sales01@aikonchem.com China 15949 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13482353728
sales@fdc-chemical.com China 9998 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068
1924344760@qq.com China 4952 58

  • POMALIDOMIDE-PEG4-CO 2 H
  • Pomalidomide-PEG4-CO2H
  • Pomalidomide-PEG4-COOH
  • Thalidomide-NH-PEG4-C2-COOH
  • Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
  • 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
  • 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Poma-PEG4-COOH
  • Pomalidomide 4'-PEG4-acid
  • 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid
  • Pomalidomide-PEG4-CO2H
  • amine-tetrapolyethyldiol-carboxylic acid
  • 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
  • 2138440-81-8
  • peg
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