tert-Butyl diethylphosphonoacetate
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- CAS-Nr.
- 27784-76-5
- Englisch Name:
- tert-Butyl diethylphosphonoacetate
- Synonyma:
- tert-butyl 2-(diethoxyphosphoryl)acetate;DIETHYL (BOC-METHYL)PHOSPHONATE;tert-Butyl diethylph;T-BUTYL DIETHYL PHOSPHONOACETATE;Tert-buty diethylphosphonoacetate;tert-Butyl diethylphosponoacetate;Tert-butyl diethylphosphonoactate;TERT-BUTYL DIETHYLPHOSPHONOACETATE;Tert-butyl diehylphosphonoacetate;Tert-butyl diethyl phosphonylacetate
- CBNumber:
- CB5708211
- Summenformel:
- C10H21O5P
- Molgewicht:
- 252.24
- MOL-Datei:
- 27784-76-5.mol
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tert-Butyl diethylphosphonoacetate Eigenschaften
- Siedepunkt:
- 100-103 °C/1.5 mmHg (lit.)
- Dichte
- 1.074 g/mL at 25 °C (lit.)
- Brechungsindex
- n20/D 1.431(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Liquid
- Wichte
- 1.074
- Farbe
- Clear colorless
- Wasserl?slichkeit
- Not miscible or difficult to mix in water.
- BRN
- 2050126
- InChI
- InChI=1S/C10H21O5P/c1-6-13-16(12,14-7-2)8-9(11)15-10(3,4)5/h6-8H2,1-5H3
- InChIKey
- NFEGNISFSSLEGU-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CP(OCC)(OCC)=O
- CAS Datenbank
- 27784-76-5(CAS DataBase Reference)
tert-Butyl diethylphosphonoacetate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Clear colorless liquid
Verwenden
tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates
Application
tert-Butyl diethylphosphonoacetate serves as an important intermediate in the synthesis of phosphonate derivatives, which are widely used in agrochemicals, pharmaceuticals, and materials science.
Synthese
Triethyl phosphite (485 g) is warmed up to 90°C under N2 atmosphere in a three-necked round-bottomed flask, and /-butyl bromoacetate (541 g) is added dropwise into the system within 2 h. Then, the mixture is stirred at 90°C for around 4 hours and cooled to room temperature. The obtained mixture is distilled under vacuo to remove compounds with low boiling points, and the residue is collected as a colorless liquid tert-butyl diethylphosphonoacetate in 97 percent yield (680 g).
tert-Butyl diethylphosphonoacetate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
tert-Butyl diethylphosphonoacetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 312)Lieferanten
27784-76-5()Verwandte Suche:
- DIETHYL(2-TERT-BUTOXYCARBONYLMETHYL)PHOSPHONATE
- (DIETHOXYPHOSPHORYL)ACETIC ACID TERT-BUTYL ESTER
- DIETHYLPHOSPHONOACETIC ACID TERT-BUTYL ESTER
- DIETHYL (TERT-BUTOXYCARBONYLMETHYL)PHOSPHONATE
- T-BUTYL DIETHYL PHOSPHONOACETATE
- TERT-BUTYL DIETHYLPHOSPHONOACETATE
- tert-Butyl diethylphosphonoacetate, 98 %
- Tert-Butyl p,p-diethylphosphonoacetate
- ACETIC ACID, 2-(DIETHOXYPHOSPHINYL)-, 1,1-DIMETHYLETHYL ESTER
- Tert-buty diethylphosphonoacetate
- tert-Butyl diethylphosphonoacetate,95%
- Tert-butyl diehylphosphonoacetate
- tert-Butyl diethylph
- (Diethoxyphosphinyl)acetic acid 1,1-dimethylethyl ester
- Diethyl tert-butoxycarbonylmethanephosphonate
- tert-Butyl (diethoxyphosphinyl)acetate
- tert-Butyl diethylphosphonoacetate
- Diethyl (Boc-methyl)phosphonate
Diethyl (tert-Butoxycarbonylmethyl)phosphonate
Diethylphosphonoacetic Acid tert-Butyl Ester
- 3-[(2-methylpropan-2-yl)oxy-oxomethyl]pentan-3-ylphosphonic acid
- Diethyl(2-tert-butoxycarbonylmethyl)phosphonate 98%
- tert-Butyl diethylphosponoacetate
- Tert-butyl diethylphosphonoactate
- tert-Butyl Diethylphosphonoacetate >
- Tert-butyl diethyl phosphonylacetate
- TERT-BUTYL DIETHYLPHOSPHONOACETATE (27784-76-5)
- 1,1-Dimethylethyl 2-(diethoxyphosphinyl)acetate
- ert-butyl2-diethoxyphosphorylacetate
- Diethyl phosphonoyl acetate tert butyl ester
- tert-Butyl 2-(diethoxy-phosphinyl)-acetate
- Diethylphosphonoyl tert butyl acetate
- DIETHYL (BOC-METHYL)PHOSPHONATE
- tert-butyl 2-(diethoxyphosphoryl)acetate
- 27784-76-5
- C2H5O2POCH2CO2CCH33
- Horner-Wadsworth-Emmons Reagents
- Olefination
- Synthetic Reagents
- C-C Bond Formation
- C-C Bond Formation
- Horner-Wadsworth-Emmons Reagents
- Olefination
- 27784-76-5
