Levocetirizine
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- CAS-Nr.
- 130018-77-8
- Englisch Name:
- Levocetirizine
- Synonyma:
- LEVOCETRIZINE;Levocetirizine-d4;(R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride;alerlisin;Cetirizine-d4;LEVOCETIRIZINE;(R)-Cetirizine;(-)-Cetirizine;(R)-Cetirizine-d4;Cetirizine R-Isomer
- CBNumber:
- CB5712207
- Summenformel:
- C21H25ClN2O3
- Molgewicht:
- 388.89
- MOL-Datei:
- 130018-77-8.mol
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Levocetirizine Eigenschaften
- Schmelzpunkt:
- 205-208°C (dec.)
- Siedepunkt:
- 542.1±45.0 °C(Predicted)
- Dichte
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
- pka
- 3.46±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Wasserl?slichkeit
- Water: 78 mg/mL (200.57 mM)
- BCS Class
- 3
- CAS Datenbank
- 130018-77-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Levocetirizine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine,
was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms),
perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be
prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by
resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more
potent H
1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold
less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers
showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to
obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well
as on histamine-induced nasal congestion and nasal resistance. There was no evidence of
chiral inversion of levocetirizine in vivo in several species including human. The daily dose
of drug is rapidly and extensively absorbed in human. Interestingly, its volume of
distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of
distribution is considered as favorable for an antihistamine both in terms of efficacy and
safety. Due to its high metabolic stability and lack of effect on the activities of the major
CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered
drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was
detected.
Chemische Eigenschaften
Off-White Solid
Verwenden
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
Levocetirizine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Levocetirizine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 186)Lieferanten
130018-77-8()Verwandte Suche:
- LEVOCETIRIZINE
- alerlisin
- LevocetirizineHydrochloride
- 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
- Cetirizine-d4
- (R)-Cetirizine
- (R)-Cetirizine Dihydrochloride
- 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
- (R)-Cetirizine-d4
- -2-(2-(4-((4-Chlorophenyl)
- Cetirizine R-Isomer
- 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
- Cetirizine Impurity 20
- (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
- Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
- Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
- Levocetirizine-IP/IHS
- LevocetirizineQ: What is
Levocetirizine Q: What is the CAS Number of
Levocetirizine Q: What is the storage condition of
Levocetirizine
- (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
- Levocetirizine Hydrochloride IP / USP
- Levocetirizine
(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid
- LevocetirizineDihydrochloride(USP)
- Benodanil Impurity 17 (Pyracarbolid)
- Levocetirizine, 10 mM in DMSO
- Levocetirizine-d4
- LEVOCETRIZINE
- (-)-Cetirizine
- 130018-77-8
- C21H21ClN2O3D4
- C21H25ClN2O3
- XYZAL
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
