1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Akt plays a role in signal transduction pathways of cell proliferation, apoptosis, angiogenesis, and diabetes. Akt1 and Akt2 dual kinase inhibitors are capable of sensitizing tumor cells to certain apoptotic stimuli, and inhibit Akt phosphorylation in vivo. Akt1 kinase activity and its regulation by extracellular signaling factors in vivo in hematopoietic cells suggests the activation of AKT1 involves intracellular translocation of the kinase from cytosol to membrane.

Biochem/physiol Actions

Isozyme selective Akt1/2 kinase inhibitor. In in vitro kinase assays, Akt1/2 kinase inhibitor shows IC50 = 58 nM, 210 nM, and 2.12 mM for Akt1, Akt2, and Akt3, respectively, The inhibition appears to be pleckstrin homology (PH) domain-dependent and the Akt1/2 kinase inhibitor has no inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 μM.

1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai Zeye Biotechnology Co., Ltd.	021-57896695 13122364865	sale1@shzysw.net	China	9779	58
Kaifeng Mingren Pharmaceutical Co.,LTD	0371-65741762	sales@hasunny.com	China	2380	58
Beijing Boorsen Biotechnology Co., Ltd	400-901-9800 18611424007	cis@bioss.com.cn	China	9185	58
Huai Hua Binfengchem Co., Ltd	0745-2866851 17711757908	406037272@qq.com	China	4383	58
bioleaper	4000880777 17585207275	guojing@bioleaper.com	China	5616	58
Cayman Chemical Company	--	sales@caymanchem.com	China	6838	58
Enzo Biochem Inc	--	Enzoname@qq.com	China	6174	58
Merck KGaA	--	ordercn@merckgroup.com	China	6394	58
Santa Cruz Biotechnology Inc	--	scbt@scbt.com	China	6594	58

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• 1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE
• AKT-I-1/2
• AKTI-1/2 TRIFLUOROACETATE SALT HYDRATE
• AKT INHIBITOR VIII TRIFLUOROACETATE SALT HYDRATE
• AKT INHIBITOR VIII
• Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one
• 2H-Imidazo[4,5-g]quinoxalin-2-one, 6-[4-[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]methyl]phenyl]-1,3-dihydro-7-phenyl-, 2,2,2-trifluoroacetate (1:)
• AKT1/2 KINASE INHIBITOR
• 616871-83-1