Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
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- CAS-Nr.
- 2225940-47-4
- Englisch Name:
- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Synonyma:
- Pomalidomide-C3-COOH;DUN 40474;Poma-C3-COOH;Thalidomide-NH-C3-COOH;Thalidomide-4-NH-C3-COOH;Pomalidomide 4'-alkylC3-acid;Pomalidomide-C3-CO2H;4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid;4-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]butanoic Acid;4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid
- CBNumber:
- CB58094242
- Summenformel:
- C17H17N3O6
- Molgewicht:
- 359.33
- MOL-Datei:
- 2225940-47-4.mol
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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Eigenschaften
- storage temp.
- 2-8°C
- Aggregatzustand
- powder or crystals
- Farbe
- Light green to green
- InChI
- 1S/C17H17N3O6/c21-12-7-6-11(15(24)19-12)20-16(25)9-3-1-4-10(14(9)17(20)26)18-8-2-5-13(22)23/h1,3-4,11,18H,2,5-8H2,(H,22,23)(H,19,21,24)
- InChIKey
- DXQHHPDVZILLOC-UHFFFAOYSA-N
- SMILES
- O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCC(O)=O)=O)NC1=O
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Protein degrader builiding block Pomalidomide-C
3-CO
2H enables the synthesis of molecules for
targeted protein degradation and
PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.
When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 65)Lieferanten
- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- DUN 40474
- Pomalidomide-C3-COOH
- 4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid
- Butanoic acid, 4[[2(2,6dioxo3piperidinyl)2,3dihydro1,3dioxo1Hisoindol4yl]amino],Butanoic acid, 4 [[2 (2,6 dioxo 3 piperidinyl) 2,3 dihydro 1,3 dioxo 1H isoindol 4 yl]amino
- Thalidomide-NH-C3-COOH
- 4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- Thalidomide-4-NH-C3-COOH
- Poma-C3-COOH
- Pomalidomide 4'-alkylC3-acid
- 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid
- Pomalidomide-C3-CO2H
- 4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid , Pomalidomide 4'-alkylC3-acid
- 4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butanoic acid
- 4-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]butanoic Acid
- 2225940-47-4
