RS 504393
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- CAS-Nr.
- 300816-15-3
- Englisch Name:
- RS 504393
- Synonyma:
- RS 504393;RS-504393; RS504393;RS504393 >=98% (HPLC);RS 504393, 10 mM in DMSO;RS 504393, CCR2 chemokine receptor antagonist;6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spir...;CC chemokine receptor,RS504393,Inhibitor,RS 504393,inhibit,CCR,RS-504393;6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidi;6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin];6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]-2(
- CBNumber:
- CB5837883
- Summenformel:
- C25H27N3O3
- Molgewicht:
- 417.5
- MOL-Datei:
- 300816-15-3.mol
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RS 504393 Eigenschaften
- Dichte
- 1.28
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble1mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)
- InChIKey
- ODNICNWASXKNNQ-UHFFFAOYSA-N
- SMILES
- N3(CCC4(OC(=O)Nc5c4cc(cc5)C)CC3)CCc1nc([o]c1C)c2ccccc2
RS 504393 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
RS 504393 is a small molecule antagonist at the CC chemokine receptor 2.
Biologische Aktivit?t
Extremely selective CCR2 chemokine receptor antagonist (IC 50 values are 98 nM and > 100 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC 50 = 330 nM) and ischemia-reperfusion injury in kidneys.
Biochem/physiol Actions
RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.
RS 504393 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
RS 504393 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 116)Lieferanten
300816-15-3()Verwandte Suche:
- Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-
- 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidi
- 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]-2(
- 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]
- RS 504393
- 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
- RS-504393; RS504393
- RS504393 >=98% (HPLC)
- 6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spir...
- CC chemokine receptor,RS504393,Inhibitor,RS 504393,inhibit,CCR,RS-504393
- 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
- RS 504393, CCR2 chemokine receptor antagonist
- RS 504393, 10 mM in DMSO
- 300816-15-3
