2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1)
|
|
|
- CAS-Nr.
- 659-40-5
- Bezeichnung:
- 2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1)
- Englisch Name:
- Hexamidine diisethionate
- Synonyma:
- SymCalmin;Desomedine;Hexamidine isethionate;HD-100;Elestab HP 100;Hexamidine 2-hydroxyethansulfonate;2535RP;HP-100;RP-2535;Esomedina
- CBNumber:
- CB5901139
- Summenformel:
- C22H32N4O6S
- Molgewicht:
- 480.58
- MOL-Datei:
- 659-40-5.mol
|
2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1) Eigenschaften
- Schmelzpunkt:
- 246-247° (dec)
- Dichte
- 671[at 20℃]
- Dampfdruck
- 0Pa at 20℃
- L?slichkeit
- Sparingly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride
- Wasserl?slichkeit
- 48.2g/L at 20℃
- Major Application
- pharmaceutical (small molecule)
- Kosmetik-Inhaltsstoffe Funktionen
- ANTI-SEBORRHEIC
PRESERVATIVE
ANTIMICROBIAL
- Erinnerung an die inhaltsstoffe
- Hexamidine diisethionate (659-40-5)
- InChIKey
- NBVZMBLJRHUOJR-UHFFFAOYSA-N
- SMILES
- C(CO)S(O)(=O)=O.O(C1C=CC(C(N)=N)=CC=1)CCCCCCOC1C=CC(C(N)=N)=CC=1
- LogP
- 4.47 at 25℃
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
2811 |
|
|
| WGK Germany |
3 |
|
|
| HazardClass |
6.1(b) |
|
|
| PackingGroup |
III |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1) Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or slightly yellow powder, hygroscopic
Verwenden
hexamidine diisethionate is an anti-microbial and preservative targeting fungi and yeast. It may also have some emollient capacities.
Application
Hexamidine Diisethionate is a preservative, antibacterial, and anti-inflammatory agent extensively used in cosmetics and personal care products. It prevents bacterial and fungal growth in formulations as well as fights off acne-causing bacteria on the skin. This synthetic ingredient is often used alongside other preservatives to enhance its effectiveness in improving the shelf life of beauty formulations. Hexamidine Diisethionate is ideal for sensitive skin to reduce redness or irritation, especially in eczema-prone or rosacea-prone skin.
Kontakt-Allergie
Hexamidine is an antiseptic active against Grampositive
bacteria and fungi, used as a disinfectant and a
preservative in cosmetics. It induces papulo-vesicular
and diffuse allergic contact dermatitis.
Toxikologie
Acute oral LD(50) values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hexamidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aqueous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethionate applied to 10% of the body surface of rats produced slight erythema, slight edema, and scabbing in some animals at varying times after treatment. Hexamidine Diisethionate was not a sensitizer in the guinea pig maximization test or in an intracutaneous guinea pig sensitization test. Hexamidine Diisethionate was not a photosensitizer in albino rabbits. Hexamidine Diisethionate was not mutagenic in a bacterial reverse mutagenicity assay or clastogenic in mammalian cells. Hexamidine Diisethionate at 0.10% did not provoke primary irritation, inflammation, or sensitization in a clinical test of 200 human subjects
[1].
2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 337)Lieferanten
659-40-5(2-Hydroxyethansulfonsure, Verbindung mit 4,4'-[Hexan-1,6-diylbis(oxy)]bis[benzolcarboxamidin] (2:1))Verwandte Suche:
- 2-Hydroxyethanesulphonic acid,compoundwith4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine](2:1)
- Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4-1,6-hexanediylbis(oxy)bisbenzenecarboximidamide (2:1)
- 2-Hydroxyethansulfonsure, Verbindung mit 4,4′-(Hexan-1,6-diylbis(oxy))bis(benzolcarboxamidin) (2:1)
- 2535RP
- Esomedina
- Ophtamedine
- RP-2535
- 4-[6-(4-Carbamimidoylphenoxy)hexoxy]benzenecarboximidamide 2-hydroxyethanesulfonnate (1:2)
- HEXAMIDINE DIISETHIONATE(HD)
- EXAMIDINE DIISETHIONATE
- Hexamidine bis (isethionate) salt
- HEXAMIDINE DIISETHIONATE
- 4,4'-(Hexane-1,6-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)
- 2-Hydroxyethanesulfonic acid - 4,4'-[1,6-hexanediylbis(oxy)]dibenzenecarboximidamide (1:1)
- 2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)
- hexamidine disethionate
- 4,4'-Diamidino-α,ω-diphenoxyhexane isethionate
- Hexamidine diisethionate, HD100,HP100
- Hexamidine diisethionate Hexamidine diisethionate
- HP-100
- 4'-[hexane-1
- 6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)
- compound with 4
- Bioactive HD 100
- 2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2
- Hexamidine diisetionate CRS
- RF 2535 {Isethionate}
- High Quality Hexamidine Diisethionate Powder CAS 659-40-5
- 4,4'-(hexane-1,6-diylbis(oxy))dibenzimidamide 2-hydroxyethanesulfonate
- Hexamidine 2-hydroxyethansulfonate
- Desomedine
- Elestab HP 100
- SymCalmin
- hexamidineisetionate
- Hexamidine bis (hydroxyethyl sulfonic acid) salt
- Hexamidine dihydroxyethyl sulfonate (acid value<1)
- Hexamidine diisethionate
HD-100
- Hexamidine Di(2-hydroxyethanesulfonate)
- Hexamidine di(hydroxyethyl sulfonate)salt
- Hexamethylenediamine di(hydroxyethylsulfonate)
- HD-100
- Hexamidine isethionate
- 659-40-5
- 556-67-5
- C20H26N4O22C2H6O4S
- API
