(-)-Bicucullinemethiodide
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- CAS-Nr.
- 40709-69-1
- Englisch Name:
- (-)-Bicucullinemethiodide
- Synonyma:
- (-)-Bicuculline methiodide;(+)-Bicuculline methiodide;(?)-Bicuculline methiodide;(-)-Bicuculline methiodide, GABAA antagonist;1(S),9(R)-(?)-Bicuculline methiodide;( ) Bicuculline methiodide,()Bicuculline methiodide;(-)-Bicuculline methiodide (mM/ml), GABAA antagonist;(-)-Bicuculline methiodide
DISCONTINUED. offer B382505;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
- CBNumber:
- CB61075225
- Summenformel:
- C21H20INO6
- Molgewicht:
- 0
- MOL-Datei:
- 40709-69-1.mol
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(-)-Bicucullinemethiodide Eigenschaften
- RTECS-Nr.
- JI4904100
- storage temp.
- Store at RT
- L?slichkeit
- H2O: soluble10mg/mL, almost clear, greenish-yellow
- Aggregatzustand
- Pale yellow solid.
- Farbe
- Yellow
- Optische Rotation
- [α]/D -117±7°, c = 1 in chloroform
- Wasserl?slichkeit
- H2O: 10mg/mL, almost clear, greenish-yellow
- BRN
- 5419649
- InChIKey
- HKJKCPKPSSVUHY-GRTNUQQKSA-M
- SMILES
- [I-].[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@]4([H])c5cc6OCOc6cc5CC[N+]4(C)C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HazardClass |
6.1 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H311 |
Giftig bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 3 |
Achtung |
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P280, P302+P352, P312, P322, P361,P363, P405, P501 |
| H330 |
Lebensgefahr bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 1 |
Achtung |
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P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P320 |
Besondere Behandlung dringend erforderlich |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
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(-)-Bicucullinemethiodide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).
Allgemeine Beschreibung
Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from
Dicentra cucullaria. It acts as an acetylcholinesteraseinhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).
Biologische Aktivit?t
Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
(-)-Bicucullinemethiodide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(-)-Bicucullinemethiodide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 32)Lieferanten
40709-69-1()Verwandte Suche:
- [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
- 1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-
- 1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-
- (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
- (-)-Bicuculline methiodide
- (-)-Bicuculline methiodide
DISCONTINUED. offer B382505
- ( ) Bicuculline methiodide,()Bicuculline methiodide
- (5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide
- (+)-Bicuculline methiodide
- (-)-Bicuculline methiodide, GABAA antagonist
- (-)-Bicuculline methiodide (mM/ml), GABAA antagonist
- 1(S),9(R)-(?)-Bicuculline methiodide
- (?)-Bicuculline methiodide
- 40709-69-1
- GABA/Glycine receptor
