O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat
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- CAS-Nr.
- 36001-88-4
- Bezeichnung:
- O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat
- Englisch Name:
- AMIPROFOS METHYL
- Synonyma:
- ntn80;ntn6867;bayntn80;NTN-2925;Tokunol-M;bayntn6867;amiprophosmethyl;AMIPROFOS METHYL;Amiprofosmethylbiochemika;C10228500 Amiprofos-methyl
- CBNumber:
- CB6124212
- Summenformel:
- C11H17N2O4PS
- Molgewicht:
- 304.3
- MOL-Datei:
- 36001-88-4.mol
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O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat Eigenschaften
- Schmelzpunkt:
- ~65 °C
- Siedepunkt:
- 146.6°C
- Dichte
- 1.275±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- -0.73±0.70(Predicted)
- Farbe
- White to Off-White
- BRN
- 2000833
- Major Application
- agriculture
environmental
- InChI
- 1S/C11H17N2O4PS/c1-8(2)12-18(19,16-4)17-11-6-5-9(3)7-10(11)13(14)15/h5-8H,1-4H3,(H,12,19)
- InChIKey
- VHEWQRWLIDWRMR-UHFFFAOYSA-N
- SMILES
- COP(=S)(NC(C)C)Oc1ccc(C)cc1[N+]([O-])=O || COP(=S)(NC(C)C)Oc1ccc(C)cc1[N+]([O-])=O
- EPA chemische Informationen
- Amiprofos-methyl (36001-88-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TB5100000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Toxizit?t |
LD50 orl-rat: 309 mg/kg 85AREA 2,212,77 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Amiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases
H. vulgare root and shoot length and inhibits
in vitro polymerization of
Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in
Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID
50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of
P. falciparum (IC
50 = 3.5 μM) and completely inhibits microtubule polymerization in
P. falciparum trophozoites at a concentration of 20 μM.
Biochem/physiol Actions
Herbicide that prevents microtubule polymerization in plant cells, but not animal cells. Crop plants resistant to amiprofos-methyl and several other herbicides have been developed by insertion of a xenobiotic-detoxifying human gene CYP2B6.
Sicherheitsprofil
A poison by ingestion. Lowtoxicity by skin contact. When heated to decomposition itemits toxic vapors of NOx, SOx, and POx.
O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 76)Lieferanten
36001-88-4(O-Methyl-O-(4-methyl-2-nitrophenyl)isopropylthiophosphoramidat)Verwandte Suche:
- amiprophosmethyl
- bayntn6867
- bayntn80
- n-isopropyl-phosphoramidothioicacio-methylo-(2-nitro-p-tolyl)ester
- ntn6867
- O-METHYL O-(2-NITRO-P-TOLYL) N-ISOPROPYL-PHOSPHORAMIDOTHIONATE
- AMIPROFOS METHYL
- ntn80
- o-methylo-(4-methyl-2-nitrophenyl)(1-methylethyl)phosphoramidothioate
- O-methyl O-(4-methyl-2-nitrophenyl) isopropylthiophosphoramidate
- Amiprofosmethylbiochemika
- O-methyl-O-(2-nitro-4-methylpehnyl)-N-isopropylphosphoramidothioate
- Tokunol-M
- N-Isopropylphosphoramidothioic acid O-methyl O-(4-methyl-2-nitrophenyl)
- NTN-2925
- Amiprofos methyl,O-Methyl O-(2-nitro-p-tolyl) N-isopropylphosphoramidothionate
- Phosphoramidothioic acid, N-(1-methylethyl)-, O-methyl O-(4-methyl-2-nitrophenyl) ester
- O-methyl O-(4-methyl-2-nitrophenyl) isopropylthiophosphorami...
- C10228500 Amiprofos-methyl
- Amiprofos methyl (Standard)
- 36001-88-4
- C11H17N2O4PS
- Biochemicals and Reagents
- BioChemical
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- Substrate Analogs
