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lacticin 481

lacticin 481 Struktur
136959-47-2
CAS-Nr.
136959-47-2
Englisch Name:
lacticin 481
Synonyma:
lacticin 481
CBNumber:
CB61374098
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

lacticin 481 Eigenschaften

Sicherheit

lacticin 481 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lacticin 481 is a tricyclic lantibiotic produced by Lactococcus lactis subsp. lactis. 

Biologische Aktivit?t

Lacticin 481 exerts its antibacterial activity via inhibition of transglycosylation involved in the biosynthesis of peptidoglycan, likely via binding to the peptidoglycan precursor lipid II.

Synthese

Lacticin 481 is a class II lantibiotic and is derived from a gene-encoded precursor peptide, which consists of an N-terminal leader peptide and a C-terminal modifiable core peptide.Lanthipeptides are characterized by the presence of lanthionine (Lan) and/or methyllanthionine (MeLan) ring structures. These are formed in a two-step process. First, dehydration of serine (S) and threonine (T) residues results in dehydroalanine (Dha) and dehydrobutyrine (Dhb). The intramolecular thioether cross-links are then formed by stereoselective 1,4-addition of cysteine thiol groups to the dehydroamino acids. (Me)Lan residues contribute to the stability of the bioactive conformation of lantibiotics and can provide protection against proteases. After these modifications, the peptide is exported, followed by cleavage of the leader by a protease, resulting in the mature, active peptide.
synthesis of lacticin 481

lacticin 481 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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  • lacticin 481
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