DIAZOACETONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Diazoacetone is used for cyclopropanation of alkenes, furans, and oxy alkenes; condensation with carbonyls and organoboranes;1,3-dipolar cycloaddition with acrylates and alkynes, yielding substituted pyrazolines and pyrazoles.
Synthesis Reference(s)
1.Arndt, F.; Amende, J. CB 1928, 61, 1122 (CA 1929, 24, 3985).
2. Wolff, L. LA 1912, 394, 23 (CA 1912, 7, 787).
Synthese
Diazoacetone is not commercially available, but can be prepared from Acetyl Chloride and Diazomethane.
1 An alternative method for preparation involves an alkaline acyl cleavage of 3-diazo- 2,4-pentanedione.
2
Lager
Diazoacetone is known to be unstable at elevated temperatures (>50 °C) and should be handled in a fume hood. The health risks associated with diazoacetone have not been evaluated. At low temperatures diazoacetone can be stored without significant decomposition.
DIAZOACETONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
