Methazolamid
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- CAS-Nr.
- 554-57-4
- Bezeichnung:
- Methazolamid
- Englisch Name:
- Methazolamide
- Synonyma:
- CL 8490;Neptaza;L 584601;Naptazane;Neptazane;Methenamide;Neptazaneat;Methazolamid;Mathazolamide;METHAZOLAMIDE
- CBNumber:
- CB6150374
- Summenformel:
- C5H8N4O3S2
- Molgewicht:
- 236.27
- MOL-Datei:
- 554-57-4.mol
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Methazolamid Eigenschaften
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22-40 |
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| S-S?tze: |
22-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AC6350000 |
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| HS Code |
2935904000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Carc. 2 |
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| Giftige Stoffe Daten |
554-57-4(Hazardous Substances Data) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Methazolamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Methazolamide is a carbonic anhydrase inhibitor (IC
50 = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED
50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC
50) value of 724 ppm, but has no activity when administered in the diet to adult
A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.
Chemische Eigenschaften
White Solid
Verwenden
Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.
Clinical Use
Methazolamide is a derivative of acetazolamide in which one of the active hydrogens has been replaced by a methyl group. This decreases the polarity and permits a
greater penetration into the ocular fluid, where it acts as a carbonic anhydrase inhibitor, reducing intraocular pressure. Its dose for glaucoma is 50 to 100 mg two to three
times a day.
Methazolamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methazolamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 214)Lieferanten
554-57-4(Methazolamid)Verwandte Suche:
- 2-acetylimino-3-methyl-delta(sup4)-1,3,4-thiadiazoline-5-sulfonamide
- 2-Acetylimino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamide
- 5-acetylimino-4-methyl-delta(sup2)-1,3,4-thiadiazoline-2-sulfonamide
- CL 8490
- N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
- N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
- N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)ethanamide
- Methazolamide (500 mg)
- MethazolaMide, USP
- 5-AcetyliMino-4-Methyl-Δ2-1,3,4-thiadiazoline-2-sulfonaMide
- L 584601
- Neptaza
- n-(4-methyl-2-sulfamoyl-△2-1,3,4-thiadiazolin-5-ylidene) acetamide
- N-[(2E)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
- (E)-N-(3-Methyl-5-sulfaMoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetaMide
- Methazolamide≥ 98% (HPLC)
- Carbonic Anhydrase IX Inhibitor III, Methazolamide
- Mathazolamide
- Methazolamide, >=99%
- 5-Acetylimino-4-methyl-delta2-1,3,4-thiadiazoline-2-sulfonamide
- Acetamide, N-(4-methyl-2-sulfamoyl-delta2-1,3,4-thiadiazolin-5-ylidene)-
- Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-
- Methenamide
- N-((2Z)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
- n-(4-methyl-2-sulfamoyl-delta(2)-1,3,4-thiadiazolin-5-ylidene)-acetamid
- n-(4-methyl-2-sulfamoyl-delta(sup2)-1,3,4-thiadiazolin-5-ylidene)-acetamid
- N-(4-Methyl-2-sulfamoyl-delta2-1,3,4-thiadiazolin-5-ylidene)acetamide
- n-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3h)-ylidene)-acetamid
- Naptazane
- Neptazane
- Neptazaneat
- METHAZOLAMIDE
- N-[4-METHYL-2-SULFAMOYL-DELTA2-1,3,4-THIADIAZOLIN-5-YLIDENE] ACETAMIDE
- N-(3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-acetamide
- Carbonic Anhydrase IX Inhibitor III, Methazolamide - CAS 554-57-4 - Calbiochem
- Methazolamide USP/EP/BP
- N-(3-Methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
- MethazolamideQ: What is
Methazolamide Q: What is the CAS Number of
Methazolamide Q: What is the storage condition of
Methazolamide Q: What are the applications of
Methazolamide
- Methazolamide (1406005)
- Methazolamid
- Methazolamide, 10 mM in DMSO
- 554-57-4
- 554-47-4
- C5H2N4O3S2D6
- C5H8N4O3S2
- Analytical Standards
- Analytical Chromatography Product Catalog
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