tasquinimod
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- CAS-Nr.
- 254964-60-8
- Englisch Name:
- tasquinimod
- Synonyma:
- TASQ);ABR-215050;tasquinimod;Tasquinimod, >98%;Tasquinimod (Standard);Tasquinimod(ABR-215050);Tasquinimod, 10 mM in DMSO;7-diMethoxy-4-quinolinyl)oxy]-;ABR-215050; ABR215050; ABR 215050;7-Dimethoxy-quinolin-4-yloxy)-phenylamine
- CBNumber:
- CB61508619
- Summenformel:
- C20H17F3N2O4
- Molgewicht:
- 406.36
- MOL-Datei:
- 254964-60-8.mol
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tasquinimod Eigenschaften
- Siedepunkt:
- 501.5±50.0 °C(Predicted)
- Dichte
- 1.427±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
- Aggregatzustand
- solid
- pka
- 4.50±1.00(Predicted)
- Farbe
- White to light yellow
- InChI
- 1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
- InChIKey
- ONDYALNGTUAJDX-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1ccc(cc1)N(C)C(=O)c2[c]([n](c3c(c2O)c(ccc3)OC)C)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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tasquinimod Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tasquinimod is an orally-active quinoline-
3-
carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.
Verwenden
Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.
tasquinimod Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
tasquinimod Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 132)Lieferanten
254964-60-8()Verwandte Suche:
- 4-Hydroxy-5-methoxy-N-methyl-1-methyl-2-oxo-N-(4-trifluoromethylphenyl)-1,2-dihydroquinoline-3-carboxamide
- N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide
- tasquinimod
- ABR-215050
- 3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-5-Methoxy-N,1-diMethyl-2-oxo-N-[4-(trifluoroMethyl)phenyl]-
- 4-Hydroxy-5-Methoxy-1-Methyl-2-oxo-1,2-
dihydro-quinoline-3-carboxylic acid Methyl-
(4-trifluoroMethyl-phenyl)-aMide
- 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-trifluoromethyl)phenyl]-3-quinolinecarboxamide
- 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c
- 4-Hydroxy-N-[4-(trifluoromethyl)phenyl]-5-methoxy-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
- ABR-215050; ABR215050; ABR 215050
- Tasquinimod, >98%
- Tasquinimod(ABR-215050)
- TASQ)
- 7-diMethoxy-4-quinolinyl)oxy]-
- 7-Dimethoxy-quinolin-4-yloxy)-phenylamine
- 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)phenyl)-1,2-dihydroquinoline-3-carboxamide
- 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide
- Tasquinimod, 10 mM in DMSO
- Tasquinimod (Standard)
- 254964-60-8
- Angiogenesis inhibitor
- S100 calcium binding protein A9 modulator
- Inhibitors
