Drinabant Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The central cannabinoid (CB
1) receptor is a G protein-
coupled receptor that is widely distributed in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ
9-
tetrahydrocannabinol. Signaling through the CB
1 receptor is implicated in attentional and working memory deficits as well as obesity. AVE-
1625 is a highly potent, selective antagonist for the CB
1 receptor with K
i values of 0.16-
0.44 nM. At 1-
3 mg/kg, AVE-
1625 significantly improves the performance of rodents in working memory tasks. At 30 mg/kg, AVE-
1625 reduces caloric intake by more than 50% of controls and significantly increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.
Drinabant Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
