2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin
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- CAS-Nr.
- 58-73-1
- Bezeichnung:
- 2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin
- Englisch Name:
- Diphenhydramine
- Synonyma:
- Benadryl;Benzhydryl;Dimedrol;DIPHENHYDRAMINE BASE;Etanautine;Restamin;Benzhydril;Benzhydramine;Difenidramina;Difenhydramin
- CBNumber:
- CB6196202
- Summenformel:
- C17H21NO
- Molgewicht:
- 255.35
- MOL-Datei:
- 58-73-1.mol
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2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin Eigenschaften
- Schmelzpunkt:
- 167-172°C
- Siedepunkt:
- bp2.0 150-165°
- Dichte
- 0.9889 (rough estimate)
- Brechungsindex
- 1.5450 to 1.5490
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Oil
- pka
- pKa 9.1 (Uncertain)
- Farbe
- Oil
- Merck
- 14,3309
- BCS Class
- 1
- InChI
- InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
- InChIKey
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N
- SMILES
- C(N(C)C)COC(C1=CC=CC=C1)C1=CC=CC=C1
- CAS Datenbank
- 58-73-1(CAS DataBase Reference)
- NIST chemische Informationen
- Ethylamine, 2-diphenylmethoxy-n,n-dimethyl-(58-73-1)
- EPA chemische Informationen
- Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl- (58-73-1)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Diphenhydramine is one of the main representatives of antihistamine drugs that block H1
receptors. Besides antihistamine activity, diphenhydramine exhibits a local anesthetic
effect, relaxes smooth muscle, and has sedative and soporific action.
Verwenden
Diphenhydramine also reduces muscle rigidity and general stiffness, and has a relatively
minor effect on tremors.
Kontakt-Allergie
This antihistaminic drug with sedative properties is
mainly sold over the counter. It can be used both topically
(treatment of pruritis) and orally for its antiallergic,
antiemetic, sedative, and anticough properties.
Allergic or photoallergic contact dermatitis and fixeddrug
eruption seem to be rare.
Sicherheitsprofil
Deadly human poison
by an unspecified route. Poison by
ingestion, intravenous, intraperitoneal, and
subcutaneous routes. Experimental
reproductive effects. Human systemic
effects by ingestion: somnolence, alteration
of operant conditioning, changes in
psychophysiological tests. Human mutation
data reported. When heated to
decomposition it emits toxic fumes of NO,.
See also ETHERS.
Environmental Fate
Diphenhydramine is fairly stable in the environment
although it does undergo photodegradation. Conjugates of
diphenhydramine such as diphenhydramine-N-glucuronide
may be converted back to the parent compound, diphenhydramine,
through enzymatic cleavage during sewage treatment
process. Diphenhydramine is removed poorly through wastewater
treatment processes and is found in significant concentrations
in aquatic organisms downstream from such plants.
Diphenhydramine has significant risk for bioaccumulation,
particularly in water downstream from wastewater and sewage
treatment facilities.
Solubility in water
One gram of diphenhydramine is soluble in 1 mL of water, 2 mL of ethanol, 2 mL of chloroform, or 50 mL of acetone; the compound is very slightly soluble in benzene or ether.
2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 270)Lieferanten
58-73-1(2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin)Verwandte Suche:
- Syntedril
- Syntodril
- Vena
- n,n-dimethyl-4,4-diphenyl-3-oxabutylamine
- AURORA KA-7664
- DIPHENHYDRAMINE
- Diphenyldramine
- 2-(Diphenylmethoxy)N,N-dimethylethylamine
- 2(diphenylmethoxy)-n,n-dimethylethylamine
- Aleryl
- Alledryl
- Allergan B
- Allergeval
- Allergical
- Allergival
- alpha-(2-Dimethylaminoethoxy)diphenylmethane
- Amidryl
- Antistominum
- Antomin
- Automin
- Bagodryl
- Baramine
- Bena
- Benachlor
- Benadrin
- Ben-allergin
- Benapon
- Benodin
- Benodine
- Benylan
- Benzantine
- Benzhydraminum
- Benzhydroamina
- Benzhydryl2-dimethylaminoethylether
- beta-(Dimethylamino)ethanol diphenylmethyl ether
- Histaxin
- Hyadrine
- Ibiodral
- Medidryl
- Mephadryl
- N-(Benzhydryloksy-etylo)dwumetyloamina
- n,n-dimethyl-2-(diphenylmethoxy)-ethylamin
- N,N-Dimethyl-2-diphenylmethyloxyethylamine
- N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine
- Nausen
- Novamina
- O-Benzhydryl(dimethylamino)ethanol
- o-benzhydryldimethylaminoethanol
- PM 255
- pm255
- Probedryl
- Restamine
- Rigidil
- Rigidyl
- S 51
- s51
- 2-benzhydryloxyethyldimethylamine
- Diphenhydramine (FDA)
