(+)-FANGCHINOLINE
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- CAS-Nr.
- 436-77-1
- Englisch Name:
- (+)-FANGCHINOLINE
- Synonyma:
- Hanfangichin B;Hanfangchin B（Fangchinoline）;(+)-limacine;Tetrandrine B;FANGCHINO-LINE;Fangchinoline-RM;(+)-FANGCHINOLINE;FANGCHINOLINE (RG);7-o-demethyltetrandrine;Fangchinoline (Standard)
- CBNumber:
- CB6221346
- Summenformel:
- C37H40N2O6
- Molgewicht:
- 608.72
- MOL-Datei:
- 436-77-1.mol
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(+)-FANGCHINOLINE Eigenschaften
- Schmelzpunkt:
- 240～242℃
- Siedepunkt:
- 709.7±60.0 °C(Predicted)
- Dichte
- 1.204±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- L?slichkeit
- Soluble in chloroform and methanol;
- pka
- 9.38±0.20(Predicted)
- Aggregatzustand
- powder to crystal
- Farbe
- White to Orange to Green
- Wasserl?slichkeit
- slightly soluble in water
- Major Application
- metabolomics
vitamins, nutraceuticals, and natural products
- InChIKey
- IIQSJHUEZBTSAT-VMPREFPWSA-N
- SMILES
- OC1C(=CC2CCN([C@@]3([H])CC4=CC=C(C(OC5=CC=C(C=C5)C[C@]5([H])N(CCC6=CC(=C(C=C65)OC=1C3=2)OC)C)=C4)OC)C)OC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2939.79.0000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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(+)-FANGCHINOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook.
f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless
needles. It is strongly laevorotatory with [α]
D - 2120 (CHCI3) and has been
shown to be the optical antipode of fanchinoline (q.v.).
Verwenden
(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
Definition
ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S
ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.
Einzelnachweise
Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)
(+)-FANGCHINOLINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(+)-FANGCHINOLINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 261)Lieferanten
436-77-1()Verwandte Suche:
- 6,6',12-TRIMETHOXY-2,2'-DIMETHYLBERBAMAN-7-OL
- (+)-FANGCHINOLINE
- FANGCHINO-LINE
- Fangchinoline,
Demethyltetrandrine
- Berbaman-7-ol,6,6',12-trimethoxy-2,2'-dimethyl-, (1β)-
- (1S)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol
- (1S)-7-Hydroxy-6,6',12-trimethoxy-2,2'-dimethylberbaman
- FANGCHINOLINE (RG)
- FANGCHINOLINE; HANFANGCHIN B
- 12-O-MethylatherosperMoline
- Tetrandrine B
- (+)-limacine
- (1-beta)-2,2’-dimethyl-6,6’,12-trimethoxyberbaman-7-ol
- 2’-dimethyl-6,6’,12-trimethoxy-(1-beta)-berbaman-7-o
- 7-o-demethyltetrandrine
- 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-, (4aS,16aS)-
- (+)-FANGCHINOLINE USP/EP/BP
- Fangchinoline, 98%, from Stephania tetrandra S. Moore
- Hanfangchin B（Fangchinoline）
- (11S,31S)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol
- 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol,3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-,(4aS,16aS)-
- Fangchinoline-RM
- Fangchinoline, 10 mM in DMSO
- Fangchinoline (Standard)
- Hanfangichin B
- 436-77-1
- C37H48N2O6
- reference substance
- Alkaloids
