Procyclidinhydrochlorid
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- CAS-Nr.
- 1508-76-5
- Bezeichnung:
- Procyclidinhydrochlorid
- Englisch Name:
- PROCYCLIDINE HYDROCHLORIDE
- Synonyma:
- PROCYCLIDINE HCL;kemadrin;D00782;Osnervan;Arpicolin;Kemadrin (tn);kemadrinhydrochloride;PROCYCLIDINE HYDROCHLORIDE;(±)-Procyclidine hydrochlorid;Procyclidine hydrochloride (usp)
- CBNumber:
- CB6229812
- Summenformel:
- C19H30ClNO
- Molgewicht:
- 323.9
- MOL-Datei:
- 1508-76-5.mol
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Procyclidinhydrochlorid Eigenschaften
- Schmelzpunkt:
- 159-164 °C
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
- InChIKey
- ZFSPFXJSEHCTTR-UHFFFAOYSA-N
- SMILES
- Cl.OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UY1926000 |
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| HS Code |
2933997500 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizit?t |
mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P403 |
An einem gut belüfteten Ort aufbewahren. |
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Procyclidinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.
Allgemeine Beschreibung
Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.
Procyclidinhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Procyclidinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 94)Lieferanten
1508-76-5(Procyclidinhydrochlorid)Verwandte Suche:
- alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanomonohydrochloride
- kemadrinhydrochloride
- PROCYCLIDINE HYDROCHLORIDE
- ALPHA-CYCLOHEXYL-ALPHA-PHENYL-1-PYRROLIDINEPROPANOL HYDROCHLORIDE
- α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol
- D00782
- Kemadrin (tn)
- Procyclidine hydrochloride (usp)
- Procyclidine Hydrochloride (200 mg)
- Arpicolin
- Osnervan
- α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol Hydrochloride
- α-Cyclohexyl-α-phenyl-1-pyrrolidinopropanol
- 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, hydrochloride
- Procyclidine Hydrochloride (1567004)
- a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride
- (±)-Procyclidine hydrochlorid
- Procyclidine HydrochlorideQ: What is
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Procyclidine-d11 Hydrochloride
- kemadrin
- Soman,Tricyclamol,inhibit,mAChR,Procyclidine,Parkinson's disease,Ionotropic glutamate receptors,anticholinergic,Inhibitor,(±)-Procyclidine,Muscarinic acetylcholine receptor,NMDA,Procyclidine hydrochloride,muscarinic receptor,epilepsy,iGluR
- -(1,2-Propanediyl)bis[1-(4-morpholinylmethyl)-2,6-piperazinedione
- Procyclidine hydrochloride in methanol
- Procyclidine hydrochloride, 10 mM in DMSO
- PROCYCLIDINE HCL
- 1508-76-5
- C19H29NOHCl
- KEMADRIN
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
