6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
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- CAS-Nr.
- 49843-98-3
- Englisch Name:
- 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
- Synonyma:
- Selisistat;EX 527 (SEN0014196);SIRT1 Inhibitor III;CS-1862;Selisista;SEN0014196;(S)-EX-527;EX 527, >=98%;EX 527; EX527;EX-527[E7034]
- CBNumber:
- CB6230650
- Summenformel:
- C13H13ClN2O
- Molgewicht:
- 248.71
- MOL-Datei:
- 49843-98-3.mol
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6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Eigenschaften
- Schmelzpunkt:
- 179.0 to 183.0 °C
- Siedepunkt:
- 531.7±38.0 °C(Predicted)
- Dichte
- 1.388
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.
- Aggregatzustand
- powder
- pka
- 16.12±0.40(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
- InChI
- InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
- InChIKey
- FUZYTVDVLBBXDL-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C2=C1C(C(N)=O)CCC2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-36 |
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| S-S?tze: |
26 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2933998090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A selective inhibitor of SIRT1 over SIRT2 and SIRT3
Allgemeine Beschreibung
A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC
50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC
50 = 19.6 and 48.7 μM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 μM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice
in vivo.
Biologische Aktivit?t
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC 50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 267)Lieferanten
49843-98-3()Verwandte Suche:
- 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
- 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE, >95%
- (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
- SEN0014196
- 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527 Selisistat
- EX 527, >=98%
- EX 527 (Selisistat)
- Selisistat 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide
- Selisistat - EX 527
- EX 527; EX527
- CS-1862
- Selisistat (SEN0014196
- SELISISTAT;EX 527;EX527;SEN0014196
- EX-527; EX-527; EX-527; SELISISTAT.
- 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide >
- (S)-EX-527
- 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-
- 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE USP/EP/BP
- Selisistat
- EX 527 (SEN0014196)
- SIRT1 Inhibitor III
- SIRT1 Inhibitor III EX-527 EX527
- EX-527/SEN0014196, EX527
- Selisista
- Pifithrin-α (PFTα) hydrobromide
- EX-527, SIRT1 Inhibitor
- 6-Chloro-2,3,4,9-tetrahydro-1H-Carbazole-1-carboxamide/Selisistat
- Selisistat, 10 mM in DMSO
- Selisistat (EX 527) ，S1541
- EX-527[E7034]
- E7034-25MG，EX-527
- 49843-98-3
- C13H13ON2Cl
- Csub1subsub3subHsub1subsub3subClNsub2subO
- Inhibitors
- Inhibitor
- Other enzyme inhibitors and activators
