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ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE Struktur
475-67-2
CAS-Nr.
475-67-2
Englisch Name:
ISOCORYDINE HYDROCHLORIDE
Synonyma:
Isocorydine;luteanin;LUTEANINE;artabotrin;Aids138466;Uzokoridin;Aids-138466;d-isocorydine;lsocorynoline;l-(+)-isocorydine
CBNumber:
CB6238999
Summenformel:
C20H23NO4
Molgewicht:
341.4
MOL-Datei:
475-67-2.mol

ISOCORYDINE HYDROCHLORIDE Eigenschaften

Schmelzpunkt:
216-220 °C(lit.)
alpha 
D20 +195° (chloroform)
Siedepunkt:
477.03°C (rough estimate)
Dichte
1.2064 (rough estimate)
Brechungsindex
1.5614 (estimate)
L?slichkeit
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Aggregatzustand
Cryst.
pka
9.41±0.20(Predicted)
Farbe
White to off-white
InChI
InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InChIKey
QELDJEKNFOQJOY-ZDUSSCGKSA-N
SMILES
N1(C)[C@]2([H])C3=C(C(OC)=C(OC)C=C3CC1)C1=C(O)C(OC)=CC=C1C2

Sicherheit

WGK Germany  3
RTECS-Nr. CE1057950
Toxizit?t LD50 intraperitoneal in mouse: 104mg/kg

ISOCORYDINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

Verwenden

sedative, cholinergic

Einzelnachweise

See Isocorydine

ISOCORYDINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ISOCORYDINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 177)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd
18283602253; +8618283602253
jancyzheng@gcgreenpure.com China 954 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+86-28-82633860; +8618080483897
sales@biopurify.com China 4616 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32467 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10236 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58

475-67-2()Verwandte Suche:


  • LUTEANINE HYDROCHLORIDE
  • 1,2,10-trimethoxy-6a-alpha-aporphin-11-o
  • 4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy
  • artabotrin
  • d-isocorydine
  • l-(+)-isocorydine
  • luteanine(aporphine)
  • D-ISOCORYDINE HYDROCHLORIDE
  • (+)-ISOCORYDINE HCL
  • ISOCORYDINE HCL, (+)-
  • (+)-ISOCORYDINE HYDROCHLORIDE
  • ISOCORYDINE HYDROCHLORIDE
  • (6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol
  • 11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE
  • 11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE HYDROCHLORIDE
  • (6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol
  • [6aS,(+)]-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol
  • S-ISOCORYDINE (+)
  • 1,2,10-Trimethoxy-6-methyl-5,6,6A,7-tetrahydro-4H-dibenzo[de,G]quinolin-11-ol
  • Aids138466
  • Aids-138466
  • Aporphin-11-ol, 1,2,10-trimethoxy-
  • (+)-isocorynoline
  • (+)-Isocorynoline hydrochloride
  • Uzokoridin
  • 4H-Dibenzo[de,g]quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)-
  • Artabotrin|||S-Isocorydine(+)|||Luteanin|||Uzokoridin|||(+)-Isocorynoline
  • lsocorynoline
  • Isocorydine
  • LUTEANINE
  • luteanin
  • 475-67-2
  • Analytical Chromatography Product Catalog
  • Analytical Standards
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Others
  • Drug Standards
  • Chromatography
  • Forensic and Veterinary Standards
  • Heterocyclic Building Blocks
  • Inhibitors
  • Miscellaneous Natural Products
  • Alkaloids
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