SINOMENINE HYDROCHLORIDE
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- CAS-Nr.
- 6080-33-7
- Englisch Name:
- SINOMENINE HYDROCHLORIDE
- Synonyma:
- Sinomenin HCl;SINOMENINE HCL;Cucoline hydrochloride;Kukoline hydrochloride;Sinomenine Hydrocloride;SINOMENINE HYDROCHLORIDE;Tuduranine Hydrochloride;Sinomenine HCl Dihydrate;Sabianine A hydrochloride;Sinomenine hydrochloride-RM
- CBNumber:
- CB6245173
- Summenformel:
- C19H23NO4.ClH
- Molgewicht:
- 365.85
- MOL-Datei:
- 6080-33-7.mol
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SINOMENINE HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 231.0 to 235.0 °C
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- H2O: soluble20mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Rotation
- [α]/D -70 to -90°, c = 1 in H2O
- Wasserl?slichkeit
- Soluble to 100 mM in water
- InChI
- InChI=1/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/s3
- InChIKey
- YMEVIMJAUHZFMW-FSYSDVFBNA-N
- SMILES
- OC1C(=CC=C2C[C@]3([H])N(CC[C@]4(CC(C(=C[C@@]43[H])OC)=O)C2=1)C)OC.Cl |&1:7,12,17,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
QD2163000 |
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| HS Code |
29334900 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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SINOMENINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-
κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-
glycoprotein.
Chemische Eigenschaften
White Solid
Verwenden
Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.
l?uterung methode
Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]
SINOMENINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SINOMENINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 279)Lieferanten
6080-33-7()Verwandte Suche:
- (9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride
- SINOMENINE HYDROCHLORIDE
- SINOMENINE HCL
- (9α,13α,14α)- 7,8-Didehydro-4-
hydroxy-3,7-diMet
- 7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl-
9α,13α,14α-Morphinan-6-one Hydrochloride
- Tuduranine Hydrochloride
- hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone
- Sinomenine Hydrocloride
- Cucoline hydrochloride
- Sinomenine hydrochloride (Cucoline hydrochloride)
- Sinomenine Hydrochloride >
- Kukoline hydrochloride
- Sabianine A hydrochloride
- TIANFU-CHEM CAS:6080-33-7 SINOMENINE HYDROCHLORIDE
- 9α,13α,14α-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride
- Sinomenine hydrochloride (Cucoline)
- Sinomenine HCl Dihydrate
- Sinomenine hydrochloride (6CI, 7CI)
- Sinomenin HCl
- 98% Sinomenine Hydrochloride Powder
- Sinomenine Hydrochloride, ≥ 98.0%
- Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9α,13α,14α)-
- (4bR,8aS,9S)-4-Hydroxy-3,7-dimethoxy-11-methyl-9,10-dihydro-5H-9,4b-(epiminoethano)phenanthren-6(8aH)-one hydrochloride
- Sinomenine hydrochloride-RM
- Sinomenine hydrochloride, Morphinan analog
- Sinomenine hydrochloride, 10 mM in DMSO
- Sinomenine hydrochloride 99%
- (4b-R,8a-S,9S)-4-hydroxy-3,7-dimethoxy-1-methyl-9,10-dihydro-5H-9,4b-(aminoethanol)phenanthrene-6(8a-H)-onehydrochloride
- Sinomenine hydrochloride (Standard)
- 6080-33-7
- C19H23NO4HCl
- Alkaloids
- Inhibitors
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- chemical reagent
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- APIs
