4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
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- CAS-Nr.
- 805239-56-9
- Englisch Name:
- 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
- Synonyma:
- PHTPP;4-[2-phenyl-5;PHTPP, 10 mM in DMSO;PHTPP, ERbeta antagonist;5-a]pyrimidin-3-yl]phenol;7-bis(trifluoromethyl)pyrazolo[1;4-[2-PHENYL-5，7-BIS(TRIFLUOROMETHYL)PYRA...;Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP;4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL;Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
- CBNumber:
- CB62453433
- Summenformel:
- C20H11F6N3O
- Molgewicht:
- 423.31
- MOL-Datei:
- 805239-56-9.mol
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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO : 25 mg/mL (59.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- Aggregatzustand
- powder
- Farbe
- yellow to orange
- InChI
- 1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
- InChIKey
- AEZPAUSGTAHLOQ-UHFFFAOYSA-N
- SMILES
- OC(C=C1)=CC=C1C(C(C2=CC=CC=C2)=N3)=C4N3C(C(F)(F)F)=CC(C(F)(F)F)=N4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
WGK 3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα. It exhibits no significant agonism on ERα or ERβ. This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in
in vitro assays.
Biologische Aktivit?t
Selective estrogen ER β receptor antagonist that displays 36-fold selectivity over ER α . Exhibits full antagonism at ER β in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ER α .
Biochem/physiol Actions
PHTPP is a selective estrogen receptor β (ERβ) full antagonist with 36-fold selectivity for ERβ over ERα. PHTPP has been used to distinguish the various activites of the two estrogen receptors. Estrogen can have opposite effects in some tumors expressing ERα compared to Erβ, with Erα enhancing and Erβ suppressing tumor cell growth. PHTPP, a selective ERβ antagonist, significantly enhanced cell growth in ovarian cancer cell lines SKOV3 and OV2008 that express both receptors.
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 92)Lieferanten
- 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
- 4-[2-phenyl-5
- 5-a]pyrimidin-3-yl]phenol
- 7-bis(trifluoromethyl)pyrazolo[1
- Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
- 4-[2-PHENYL-5，7-BIS(TRIFLUOROMETHYL)PYRA...
- Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP
- PHTPP, ERbeta antagonist
- PHTPP, 10 mM in DMSO
- PHTPP
- 805239-56-9
- C20H11F6N3O
