2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
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- CAS-Nr.
- 321674-73-1
- Englisch Name:
- 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
- Synonyma:
- CS-1061;BIBR 1532;BIBR 1532, >=98%;BIBR 1532;BIBR-1532;Telomerase Inhibitor X;BIBR 1532, 10 mM in DMSO;(E)-2-(3-phenylbut-2-enamido)benzoic acid;2-[3-(2-Naphthyl)but-2-enamido]benzoic Acid;2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID;(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
- CBNumber:
- CB62456353
- Summenformel:
- C21H17NO3
- Molgewicht:
- 331.36
- MOL-Datei:
- 321674-73-1.mol
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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Eigenschaften
- Schmelzpunkt:
- >173oC (dec.)
- Siedepunkt:
- 600.6±48.0 °C(Predicted)
- Dichte
- 1.284
- storage temp.
- Store at RT
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- pka
- 3.46±0.36(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
- InChIKey
- PGFQXGLPJUCTOI-WYMLVPIESA-N
- SMILES
- C(O)(=O)C1=CC=CC=C1NC(=O)/C=C(/C1=CC=C2C(=C1)C=CC=C2)\C
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC
50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.
Biologische Aktivit?t
Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 174)Lieferanten
321674-73-1()Verwandte Suche:
- 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
- BIBR 1532
- 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
- 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid
- (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
- BIBR 1532, >=98%
- BIBR 1532;BIBR-1532
- CS-1061
- (E)-2-(3-phenylbut-2-enamido)benzoic acid
- Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-
- 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID USP/EP/BP
- Telomerase Inhibitor X
- 2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID
- BIBR 1532, 10 mM in DMSO
- 2-[3-(2-Naphthyl)but-2-enamido]benzoic Acid
- 321674-73-1
- Inhibitors
- API
