7-Ethyl-10-hydroxycamptothecin
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- CAS-Nr.
- 130144-34-2
- Englisch Name:
- 7-Ethyl-10-hydroxycamptothecin
- Synonyma:
- Camptothecin Impurity 21;7-Ethyl-10-hydroxycamptothecin;(rac)-7-Ethyl-10-Hydroxy camptothecin;rac-4,11-Diethyl-9-hydroxycamptothecin;7-Ethyl-10-hydroxycamptothecin, racemic;7-Ethyl-10-Hydroxycamptothecin7-Ethyl-10-Hydroxycamptothecin;1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- CBNumber:
- CB62462141
- Summenformel:
- C22H20N2O5
- Molgewicht:
- 392.41
- MOL-Datei:
- 130144-34-2.mol
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7-Ethyl-10-hydroxycamptothecin Eigenschaften
- Siedepunkt:
- 810.3±65.0 °C(Predicted)
- Dichte
- 1.51
- pka
- 9.13±0.40(Predicted)
- InChI
- InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3
- InChIKey
- FJHBVJOVLFPMQE-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
Sicherheit
7-Ethyl-10-hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
7-Ethyl-10-hydroxycamptothecin: a potent topoisomerase I inhibitor
7-Ethyl-10-hydroxycamptothecin (SN-38), as a highly active topoisomerase (Topo) I inhibitor, is the active metabolic product of its prodrug irinotecan (CPT-11) commercially available as Camptosar. By combining with the Topo I-DNA covalent conjugate, the camptothecin analogue forms a ternary complex that blocks the repolymerization of the DNA strands during their replication, eventually leading to the cell apoptosis. Although SN-38 is about 100- to 1000-fold more potent than irinotecan, its clinical application is limited by its poor solubility and nonspecific toxicity[1].
7-Ethyl-10-hydroxycamptothecin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-Ethyl-10-hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 94)Lieferanten
- 7-Ethyl-10-hydroxycamptothecin
- 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-
- (rac)-7-Ethyl-10-Hydroxy camptothecin
- rac-4,11-Diethyl-9-hydroxycamptothecin
- 7-Ethyl-10-hydroxycamptothecin, racemic
- Camptothecin Impurity 21
- 7-Ethyl-10-Hydroxycamptothecin7-Ethyl-10-Hydroxycamptothecin
- 130144-34-2
- 86639-52-8
- 86639-52-2
