Besifloxacin hydrochloride
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- CAS-Nr.
- 405165-61-9
- Englisch Name:
- Besifloxacin hydrochloride
- Synonyma:
- Besifloxacin HCl;CS-781;Pranoprofer;BOL-303224-A;Unii-7506A6J57t;Besifloxacin HC;Besivance hydrochloride;Hydrochloric Besifloxacin;7-[(3R)-3-AMinohexahydro-;Becifloxacin Hydrochloride
- CBNumber:
- CB62492988
- Summenformel:
- C19H21ClFN3O3.ClH
- Molgewicht:
- 430.3
- MOL-Datei:
- 405165-61-9.mol
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Besifloxacin hydrochloride Eigenschaften
- Schmelzpunkt:
- >210°C (dec.)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- Methanol (Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Light Beige
- InChI
- InChI=1/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H/t10-;/s3
- InChIKey
- PMQBICKXAAKXAY-MEQOOBBNNA-N
- SMILES
- ClC1C(N2CCCC[C@@H](N)C2)=C(F)C=C2C(=O)C(C(=O)O)=CN(C3CC3)C=12.Cl |&1:8,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Besifloxacin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Besifloxacin is a new fluoroquinolone antibacterial for ophthalmic
use. It is indicated for the treatment of bacterial conjunctivitis, one of
the most common ocular infections encountered in the primary care
setting. Although the previously marketed fluoroquinolones ciprofloxacin, levofloxacin, ofloxacin, gatifloxacin, and moxifloxacin have been
widely used to treat bacterial conjunctivitis, their continued utility is
hampered by the emergence of resistance among key ocular isolates
such as Staphylococcus aureus. Besifloxacin is the first
fluoroquinolone developed exclusively for topical ophthalmic use.
Unlike the previously marketed fluoroquinolones, besifloxacin has not
been used systemically and is not in development as a systemic agent. Its
exclusive indication as a topical agent is expected to reduce the overall
environmental exposure of bacteria to besifloxacin, which may contribute to a lower risk for the emergence of bacterial resistance. Fluoroquinolones derive their antibacterial activity via inhibition of two essential
bacterial enzymes, DNA gyrase and topoisomerase IV, which regulate
processes of DNA replication. Besifloxacin inhibits DNA gyrase and topoisomerase IV from Streptococcus pneumoniae (IC50 = 1 and 0.4 mg/ L, respectively) and Escherichia coli (IC50 = 1 and 10 mg/L, respectively).
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic
Nebenwirkungen
The most common adverse event reported in patients treated with besifloxacin ophthalmic suspension was conjunctival redness. Other less common adverse events were blurred vision, eye pain, eye irritation, eye pruritus, and headache.
Besifloxacin hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Besifloxacin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 259)Lieferanten
405165-61-9()Verwandte Suche:
- (R)-7-(3-AMinohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid HCl
- 3-Quinolinecarboxylic acid, 7-[(3R)-3-aMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI)
- (R)-7-(3-aMinoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- Unii-7506A6J57t
- (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride
- Besifloxacin hydrochloride
- Becifloxacin Hydrochloride
- BESIFLOXACIN HCL INTERMEDIATES
- Hydrochloric Besifloxacin
- 3-Quinolinecarboxylic acid, 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)
- Besifloxacin HCl (Besivance)
- Besifloxacin hydrochloride, >=98%
- 7-[(3R)-3-AMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride
- 7-[(3R)-3-AMinohexahydro-
- Besifloxacin HC
- CS-781
- Besifloxacin hydrochloride (405165-61-9)
- Besivance hydrochloride
- BOL-303224-A
- Besifloxacin hydrochloride USP/EP/BP
- Besifloxacin Hydrochloride (Contains ~15% Inorganics)
- Besifloxacin Hcl Intermediate
- 7-(3-aminoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- Pranoprofer
- 7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- Besifloxacin Hydrochloride, 10 mM in DMSO
- Besifloxacin HCl - Bio-X ?
- Besifloxacin HCl
- 405165-61-9
- C19H21ClFN3O3HCl
- C19H22Cl2FN3O3
- C19H21ClFN3O3ClH
- API
- Inhibitors
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
