Formestane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Formestane is a potent aromatase inhibitor launched in the UK as a second-line endocrine treatment for breast cancer. As a synthetic derivative of androstanedione, the natural substrate for the biosynthesis of estrogen by the enzyme aromatase, formastane selectively inhibits aromatase and binds to its steroid receptor site to cause a rapid and sustained fall in circulating estrogen level and, therefore, inhibits tumor growth. In patients with existing bulky primary tumors, formestane effectively reduces the size of the tumors. Formastane has apparent tolerability advantages and less side effects than other agents such as aminoglutethimide.

Chemische Eigenschaften

Needles

Definition

ChEBI: A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or proho mones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subseque t development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.

Mechanism of action

Aromatase inhibitors such as formestane and letrozole reduce plasma estradiol levels by inhibiting the conversion of testosterone to estrogen. This compound was first described as a competitive inhibitor, but subsequent evidence proved that its binding to aromatase was irreversible. Hence, it is a suicide inhibitor. In the dog, but not rodents, this results in Leydig cell hypertrophy and hyperplasia. This is thought to be due to the differential sensitivity of the pituitary feedback mechanism to estrogens and androgens in the different species[1-2].

Formestane Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Formestane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8737	58
Nantong Guangyuan Chemicl Co,Ltd	+86-17331189928	admin@guyunchem.com	China	611	58
Rixing Chemical CO.,LTD	+86-13237129059 -13237129059	sales@rixingchemi.com	CHINA	227	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 13734021967	kaia@neputrading.com	China	991	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
.GZ HONESTCHEM CO.,LTD	+86-15013270415	honestchemical@foxmail.com	China	294	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	955	58
Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Hebei Henghe Import and Export Trading Co. LTD	+8618032935937 18032916000	demi@hbtycoon.com	CHINA	445	58

566-48-3()Verwandte Suche:

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• 4-hydroxy-androst-4-ene-17-dione
• 4-hydroxy-delta(sub4)-androstenedione
• 4-HYDROXYANDROST-4-ENE-3,17-DIONE
• 4-HYDROXYANDROSTENEDIONE
• 4-HYDROXY-4-ANDROSTENE-3,17-DIONE
• 4-ANDROSTEN-4-OL-3,17-DIONE
• 4-OHA
• CGP-32349
• FROMESTANE
• FORMESTANE
• FORMESTAQNE
• LENTARON
• Formesatane
• FORMESTANE 98%
• FORMESTANE,4-HYDROXYANDROST-4-ENE-3,17-DIONE
• 4-ANDROSTENE-4-OL-3,17-DIONE
• 4-Hydroxyandrost-4-ene-3,17-dione, 4-OHA, CGP-32349, Lentaron
• FORMASTANE/FORMESTANE/4-ANDROSTEN-4-OL-3,17-DIONE
• 4-ANDROSTEN-4-OL-3,17-DIONE(FORMESTANE)
• B, Aromatase inhibitor
• 6-hydroxy-10,13-dimethyl- 1,7,8,9,10,11,12,13,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17(6H,14H)-dione
• 4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349
• 4-Hydroxyandrostan-4-ene-3,17-dione
• (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
• (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone
• 4-Hydroxy-4-androstenedione
• 4-Hydroxyandrostendione (Formestane)
• NSC 282175
• CGP-32349：Lentaron
• Androst-4-ene-3,17-dione,4-hydroxy-
• Stan FuMei
• (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-1,7,8,9,10,11,12,13,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17(6H,14H)-dione
• Anti-Cytochrome P450 19A1 antibody produced in rabbit
• CYPXIX
• Cytochrome P450 19A1
• Estrogen synthetase
• P-450AROM
• Lentaron Formestane
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• Anti-Estrogens Steroids Raw Powder Formestane
• Formestane(4-hydroxy-androstenedione)
• Formestane (CGP-32349)
• TIANFU CHEM- Formestane
• Formestane Lentaron Raw Powder
• Carbon Isotope Delta Value (d13CVPDB / ‰): Formestane (–30.71 ± 0.48)* (for WADA labs, only)
• 566-48-3
• Enzymes, Inhibitors, and Substrates
• Enzyme Inhibitors
• Enzyme Inhibitors by Enzyme
• 多肽抗原
• 小鼠抗人和大、小鼠、犬、豬、牛芳香化酶多克隆抗體
• Aromatase
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