QS11
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- CAS-Nr.
- 944328-88-5
- Englisch Name:
- QS11
- Synonyma:
- QS11;CS-346;BML-WN117;QS11 free;QS11 hydrate;QS11;BML-WN117;Wnt Synergist, QS11;QS11, 10 mM in DMSO;QS11, ARFGAP1 inhibitor;Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem
- CBNumber:
- CB62517933
- Summenformel:
- C36H33N5O2
- Molgewicht:
- 567.69
- MOL-Datei:
- 944328-88-5.mol
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QS11 Eigenschaften
- Siedepunkt:
- 852.2±75.0 °C(Predicted)
- Dichte
- 1.27
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Pale amber solid
- pka
- 14.46±0.10(Predicted)
- Farbe
- White to off-white
- InChIKey
- DOKZLKDGUQWMSX-HKBQPEDESA-N
- SMILES
- [n]3(c4nc(nc(c4nc3)N[C@H](CO)Cc7ccccc7)Oc5cc6c(cc5)CCC6)Cc1ccc(cc1)c2ccccc2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 2 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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QS11 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM. It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC
50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC
50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.
Verwenden
QS 11 is a small molecule Wnt synergistic agonist.
QS11 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
QS11 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
- QS11
- (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
- (betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
- QS11 hydrate
- Wnt Synergist, QS11
- (S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)
- QS 11
(betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
- (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
- Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem
- (S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol
- CS-346
- BML-WN117
- QS11;BML-WN117
- Benzenepropanol, β-[[9-([1,1'-biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]-, (βS)-
- synergistic,Wnt,regenerative,agonist,signaling,factors,Inhibitor,QS11,inhibit,ADP-ribosylation,QS-11
- QS11, ARFGAP1 inhibitor
- QS11, 10 mM in DMSO
- QS11 free
- 944328-88-5
- C36H33N5O2
