2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
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- CAS-Nr.
- 883031-03-6
- Englisch Name:
- 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
- Synonyma:
- HC 067047;Avutrombopag;HC-067047 (HC067047;HC-067047 >=98% (HPLC);HC-067047, 10 mM in DMSO;HC 067047, TRPV4 antagonist;TRPV4 Antagonist II, HC-067047;Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit;2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide;2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
- CBNumber:
- CB62518965
- Summenformel:
- C26H28F3N3O2
- Molgewicht:
- 471.51
- MOL-Datei:
- 883031-03-6.mol
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2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥15mg/mL
- Aggregatzustand
- powder
- Farbe
- white to tan
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- NCZYSQOTAYFTNM-UHFFFAOYSA-N
- SMILES
- CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
HC-067047has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4)inhibitor:
- to study its effects on organoid formation and proliferation in human endometrial tissues
- to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
- to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus
Biochem/physiol Actions
HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC50 values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC50 values of 370 and 780 nM, respectively.
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
883031-03-6()Verwandte Suche:
- 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
- HC 067047
- 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
- 1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
- HC-067047 >=98% (HPLC)
- Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit
- HC 067047, TRPV4 antagonist
- HC-067047, 10 mM in DMSO
- TRPV4 Antagonist II, HC-067047
- HC-067047 (HC067047
- Avutrombopag
- 883031-03-6
- C26H28F3N3O2
- Potent and selective TRPV4 antagonist.
