(R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid
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- CAS-Nr.
- 51773-92-3
- Bezeichnung:
- (R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid
- Englisch Name:
- Mefloquine hydrochloride
- Synonyma:
- MEFLOQUINE HCL;Loriam;wr14249;wr142490;Ro 21-5998/001;Mefloquine HCI;s*)-(r(+-)-lorid;Mefloquin hydrochloride;efloquine hydrochloride;MEFLOQUINE HYDROCHLORIDE
- CBNumber:
- CB6252498
- Summenformel:
- C17H16F6N2O.ClH
- Molgewicht:
- 414.77
- MOL-Datei:
- 51773-92-3.mol
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(R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid Eigenschaften
- Schmelzpunkt:
- 250-254C
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 38 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 8.6
- Farbe
- white
- maximale Wellenl?nge (λmax)
- 222nm(Acidic H2O)(lit.)
- Merck
- 14,5801
- BCS Class
- 4/2
- Stabilit?t:
- Temperature Sensitive
- InChI
- InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
- InChIKey
- WESWYMRNZNDGBX-YLCXCWDSSA-N
- SMILES
- C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
- CAS Datenbank
- 51773-92-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
VC0308000 |
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| HS Code |
2933399090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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(R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Beschreibung
Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination
with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria.
Administered once weekly, the combination is effective against pathogens
resistant to other agents.
Chemische Eigenschaften
White Solid
Verwenden
Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.
Allgemeine Beschreibung
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Clinical Use
The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.
(R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 280)Lieferanten
51773-92-3((R*,S*)-(±)-α-2-Piperidyl-2,8-bis(trifluormethyl)chinolin-4-methanolmonohydrochlorid)Verwandte Suche:
- 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanomonohydroch
- dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol
- s*)-(r(+-)-lorid
- Mefloquin hydrochloride
- wr14249
- (αS)-rel-α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, hydrochloride (1:1)
- Mefloquine hydrochloride, >=99%
- (R)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-[(2S)-2-piperidyl]methanol hydrochloride
- wr142490
- Mefloquine Hydrochloride, USP
- (R)-[2,8-bis(trifluoroMethyl)quinolin-4-yl](2R)-piperidin-2-ylMethanol
- (S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride
- MEFLOQUINE HYDROCHLORIDE
- (AS)-REL-A-(2R)-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL MONOHYDROCHLORIDE
- (2r)-(+/-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
- (2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PIPERIDIN-2-YL-METHANOL HYDROCHLORIDE(R*,S*)
- (R*,S*)-(±)-alpha-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
- MEFLOQUINE HYDROCHLORIDE EP(CRM STANDARD)
- (R*,S*)-(+-)-a-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
- 4-Quinolinemethanol, 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-, monohydrochloride, (R*,S*)-, (+-)
- DL-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride
- Loriam
- (R*,S*)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol hydrochloride
- Ro 21-5998/001
- Mefloquine Hydrochloride (100 mg)
- (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
- (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
- (R)-[2,8-bis(trifluoromethyl)-4-quinolinyl][(2S)-2-piperidinyl]methanol hydrochloride
- MefloquineHydrochloride>
- Mefloquine hydrochloride CRS
- Mefloquine Hydrochloride (Polymorph Form E)
- 4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel-
- efloquine hydrochloride
- rel-(S)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride
- Mefloquine HCl (Mefloquin)
- Mefloquine hydrochlorideQ: What is
Mefloquine hydrochloride Q: What is the CAS Number of
Mefloquine hydrochloride Q: What is the storage condition of
Mefloquine hydrochloride Q: What are the applications of
Mefloquine hydrochloride
- Mefloquine Hydrochloride (1379059)
- (RS)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-(SR)-(2-piperidyl)methanol hydrochloride
- Mefloquine hydrochloride, 10 mM in DMSO
- Mefloquine hydrochloride 100 μg/mL in Acetonitrile
- Mefloquine for system suitability CRS
- 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
- Mefloquine HCI
- MEFLOQUINE HCL
- 51773-92-3
- C17H16F6N2OHCl
- C17H16F6N2OClH
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
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