P7C3
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- CAS-Nr.
- 301353-96-8
- Englisch Name:
- P7C3
- Synonyma:
- P7C3;CS-1463;P7C3, >97%;P7C3, >=98%;P7C3; 301353-96-8;P7C3, 10 mM in DMSO;1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol;P7C3, pro-neurogenic and neuroprotective compound;6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol;3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
- CBNumber:
- CB62535687
- Summenformel:
- C21H18Br2N2O
- Molgewicht:
- 474.19
- MOL-Datei:
- 301353-96-8.mol
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P7C3 Eigenschaften
- Siedepunkt:
- 656.4±55.0 °C(Predicted)
- Dichte
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble34mg/mL
- pka
- 13.91±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
- InChI
- 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
- InChIKey
- FZHHRERIIVOATI-UHFFFAOYSA-N
- SMILES
- OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
P7C3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury. While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.
Verwenden
P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.
Biochem/physiol Actions
P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
P7C3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
P7C3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 115)Lieferanten
- 1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(PHENYLAMINO)PROPAN-2-OL
- 3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol
- P7C3, >=98%
- 6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
- P7C3; 301353-96-8
- CS-1463
- P7C3, >97%
- 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
- 9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(phenylamino)methyl]-
- P7C3,inhibit,injury,Inhibitor,nerve,neurodegeneration,neuroprotective,Parkinson's,neurodegenerative diseases,disease,cell,P-7C3
- 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
- P7C3, pro-neurogenic and neuroprotective compound
- P7C3, 10 mM in DMSO
- P7C3
- 301353-96-8
- Inhibitors
- API
