SteMRegenin 1
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- CAS-Nr.
- 1227633-49-9
- Englisch Name:
- SteMRegenin 1
- Synonyma:
- SR1;SR-1;CS-873;SR-1;SR1;Novartis SR1;etMRegenin 1;SteMRegenin 1;SetmRegenin 1;SetMEegenin 1;SR 1;SR-1;SR1
- CBNumber:
- CB62560979
- Summenformel:
- C24H23N5OS
- Molgewicht:
- 429.54
- MOL-Datei:
- 1227633-49-9.mol
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SteMRegenin 1 Eigenschaften
- Siedepunkt:
- 604.9±65.0 °C(Predicted)
- Dichte
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- L?slichkeit
- Soluble in DMSO (up to 10 mg/ml).
- Aggregatzustand
- White solid
- pka
- 10.03±0.15(Predicted)
- Farbe
- Off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
- InChIKey
- BGFHMYJZJZLMHW-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(CCNC2=C3C(=NC(C4=CSC5=CC=CC=C54)=N2)N(C(C)C)C=N3)C=C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
WGK 3 |
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| HS Code |
2934999090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SteMRegenin 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Application
StemRegenin 1 can also be used to treat infectious diseases such as HIV/AIDS, malaria, and tuberculosis. The mechanism by which StemRegenin 1 stimulates the production of new red blood cells is not well understood; however, it appears to work through activation of JAK1. This protein inhibits the polymerase chain reaction (PCR), which is an enzyme that increases the rate at which DNA copies are made from a template molecule. Inhibitors of this enzyme have been shown to prevent infection with Human Immunodeficiency Virus (HIV) in vitro.
Allgemeine Beschreibung
A cell-permeable purine compound that acts as a high affinity AhR antagonist (IC
50 = 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), but not a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No.
182705), or SR1 treatment all result in enhanced and sustained CD34
+ population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No.
605218), SCF (Cat. No.
569600), Flt3 Ligand (Cat. No.
343010), and IL-6 (Cat. No.
407652) in a reversible manner. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.
Verwenden
StemRegenin 1 is a plant-derived stem cell factor that is potent inducers of hematopoietic stem cells. It has been shown to stimulate the differentiation and proliferation of primary cells, such as human umbilical cord blood cells and bone marrow cells, into mature erythrocytes and leukocytes.
SteMRegenin 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SteMRegenin 1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 143)Lieferanten
1227633-49-9()Verwandte Suche:
- Novartis SR1
- SteMRegenin 1 (SR1)
- SetMEegenin 1
- 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol
- SetmRegenin 1
- 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol StemRegenin 1
- SteMRegenin 1 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol
- SteMRegenin 1
- 4-(2-(2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylaMino)ethyl)phenol
- SR1
- SR-1
- SR-1;SR1
- Phenol, 4-[2-[[2-benzo[b]thien-3-yl-9-(1-Methylethyl)-9H-purin-6-yl]aMino]ethyl]-
- etMRegenin 1
- StemRegenin 1, Free base
- StemRegenin 1, >=98%
- AhR Antagonist II, SR1
- AhR Antagonist II, SR1 - CAS 1227633-49-10 - Calbiochem
- SetmEegenin 1, >98%
- SR 1;SR-1;SR1
- CS-873
- SteMRegenin 1 USP/EP/BP
- StemRegenin 1 hydrochloride, AhR antagonist
- StemRegenin 1, 10 mM in DMSO
- 1227633-49-9
- Antineoplastic
- apis
- Inhibitors
