3-bromo-5-phenyl Salicylic Acid
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- CAS-Nr.
- 4906-68-7
- Englisch Name:
- 3-bromo-5-phenyl Salicylic Acid
- Synonyma:
- NSC-109116;AKR1C1-IN-1;AKR1C1-IN-1, 10 mM in DMSO;XVZSXNULHSIRCQ-UHFFFAOYSA-N;3-bromo-5-phenylsalicyclic acid;3-bromo-5-phenyl Salicylic Acid;3-bromo-5-phenyl Salicylic Acid Exclusive;5-Bromo-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-
- CBNumber:
- CB62590019
- Summenformel:
- C13H9BrO3
- Molgewicht:
- 293.11
- MOL-Datei:
- 4906-68-7.mol
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3-bromo-5-phenyl Salicylic Acid Eigenschaften
- Schmelzpunkt:
- 212-214 °C
- Siedepunkt:
- 401.2±45.0 °C(Predicted)
- Dichte
- 1.611±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 0.1 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 2.45±0.14(Predicted)
- Farbe
- White to pink
- InChI
- 1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
- InChIKey
- XVZSXNULHSIRCQ-UHFFFAOYSA-N
- SMILES
- OC1=C(C(O)=O)C=C(C2=CC=CC=C2)C=C1Br
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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3-bromo-5-phenyl Salicylic Acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The aldo-
keto reductase (AKR) enzymes constitute a family of related NADPH-
dependent oxidoreductases. The
1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-
HSD and the other three being 3α-
HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-
hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-
bromo-
5-
phenyl Salicylic acid selectively inhibits AKR1C1 (K
i = 4 nM) over AKR1C2 (K
i = 87 nM), AKR1C3 (K
i = 4.2 μM), and AKR1C4 (K
i = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC
50 = 460 nM).
3-bromo-5-phenyl Salicylic Acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-bromo-5-phenyl Salicylic Acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 45)Lieferanten
4906-68-7()Verwandte Suche:
- 3-bromo-5-phenyl Salicylic Acid
- 3-bromo-5-phenyl Salicylic Acid Exclusive
- XVZSXNULHSIRCQ-UHFFFAOYSA-N
- AKR1C1-IN-1
- [1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-
- 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
- NSC-109116
- 3-bromo-5-phenylsalicyclic acid
- inhibit,AKR-1C1-IN-1,progesterone,AKR1C1IN1,AKR1C1 IN 1,Inhibitor,AKR1C1
- 5-Bromo-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid
- AKR1C1-IN-1, 10 mM in DMSO
- 4906-68-7
