(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

1268524-71-5

CAS-Nr.: 1268524-71-5

Englisch Name:: (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Synonyma:: tert-Butyl (R)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(-)-JQ-1;(R)-(-)-JQ1;JQ-1;JQ1;-JQ1;JQ 1;(R)-(-)-JQ1 Enantiomer;(-)-JQ-1;(R)-(-)-JQ1 ENANTIOMER;(R)-(-)-JQ1 Enantiomer, 10 mM in DMSO;(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-...;(R)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3-a][1;(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]

CBNumber:: CB62604226

Summenformel:: C23H25ClN4O2S

Molgewicht:: 456.99

MOL-Datei:: 1268524-71-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 107

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Eigenschaften

Siedepunkt:: 610.4±65.0 °C(Predicted)

Dichte: 1.33

storage temp.: 2-8°C

L?slichkeit: DMSO: soluble20mg/mL, clear

pka: 2.05±0.60(Predicted)

Aggregatzustand: powder

Farbe: white to beige

InChI: 1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1

InChIKey: DNVXATUJJDPFDM-QGZVFWFLSA-N

SMILES: O=C(OC(C)(C)C)C[C@@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(R)-(-)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate is the enantiomer of (S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (T117580), which is BET bromodomain inhibitor, also activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.

Allgemeine Beschreibung

JQ1 is a member of the triazolo-diazepine compound family which functions as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. Its core structure is composed of thienodiazepine.

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

(+)-JQ-1 4-tert-Butylhydrogen-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartat Acetohydrazid (±)-JQ1 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)- Butanoic acid, 3-aMino-4-[[3-(4-chlorobenzoyl)-4,5-diMethyl-2-thienyl]aMino]-4-oxo-, 1,1-diMethylethyl ester, (3S)- 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene Butanoic acid, 4-[[3-(4-chlorobenzoyl)-4,5-diMethyl-2-thienyl]aMino]-3-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]-4-oxo-, 1,1-diMethylethyl ester, (3S)-

Downstream Produkte

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 107)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6290	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25333	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	China	8433	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9937	58

(R)-(-)-JQ1 Enantiomer
(R)-(-)-JQ1
(R)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3-a][1
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
(-)-JQ-1
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]
JQ-1;JQ1;-JQ1;JQ 1
(6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
(-)-JQ-1;(R)-(-)-JQ1 ENANTIOMER
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-...
(R)-6-(Boc-methyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
inhibit,Inhibitor,(R)-(-)-JQ-1 Enantiomer,(R) ( ) JQ1 Enantiomer,(R)()JQ1 Enantiomer,Epigenetic Reader Domain
(R)-(-)-JQ1 Enantiomer, 10 mM in DMSO
tert-butyl 2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
tert-Butyl (R)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
1268524-71-5
268524-71-5
Inhibitor

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