rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride
|
|
|
- CAS-Nr.
- 949588-40-3
- Englisch Name:
- rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride
- Synonyma:
- Org 25935;SCH-900435;SCH 900435;ORG25935-SCH900435;ORG 25935 hydrochloride;2-[[(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino]acetic acid;rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride
- CBNumber:
- CB62651417
- Summenformel:
- C21H26ClNO3
- Molgewicht:
- 375.89
- MOL-Datei:
- 949588-40-3.mol
|
rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride Eigenschaften
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
|
|
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Enzyminhibitor
This synthetic drug (FW = 339.43 g/mol; CAS 949588-40-3), known systematically as 2-([(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen- 2-yl]methylmethylamino)acetate, is a selective inhibitor of the sodium/chloride-dependent glycine transporter GlyT1, counteracting the effects of the dissociative drug ketamine. Rationale: Elevation of extracellular synaptic concentration of glycine by blockade of GlyT1 is believed to potentiate NMDA receptor function in vivo, thereby suggesting a rational approach for the treatment of schizophrenia and cognitive disorders. Moreover, accumbal glycine receptors (GlyRs) are involved in mediating the dopamine activating effects of ethanol, and that administration of glycine locally into the nucleus accumbens (nAc) reduces ethanol consumption in ethanol high-preferring rats. Org-25935 decreased ethanol intake and ethanol preference, as compared with vehicle, whereas water intake was unaffected. This effect was dose-dependent, developed gradually and was sustained for up to 40 days Note: Other GlyT1 inhibitors include GSK931145, Lu AA21279, NFPS, Org 25935, SB-710622, SSR 504734, whereas D-serine is an agonist. All GlyT1 inhibitors increased seizure thresholds dose-dependently, indicative of anticonvulsant activity.
rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 9)Lieferanten
- Org 25935
- rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride
- 2-[[(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino]acetic acid
- ORG 25935 hydrochloride
- SCH 900435
- SCH-900435
- ORG25935-SCH900435
- 949588-40-3
