AZD2461
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- CAS-Nr.
- 1174043-16-3
- Englisch Name:
- AZD2461
- Synonyma:
- 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one;CS-739;AZD2461;AZD2461 ，S7029;AZD 2461, >=98%;AZD2461 AZD-2461;AZD2461 USP/EP/BP;AZD-2461, 10 mM in DMSO;4-(4-Fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one;4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
- CBNumber:
- CB62655394
- Summenformel:
- C22H22FN3O3
- Molgewicht:
- 395.43
- MOL-Datei:
- 1174043-16-3.mol
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AZD2461 Eigenschaften
- Dichte
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic
- pka
- 12.07±0.40(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
- InChIKey
- HYNBNUYQTQIHJK-UHFFFAOYSA-N
- SMILES
- O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=CC=CC=C41
AZD2461 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.
Biochem/physiol Actions
AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.
AZD2461 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
AZD2461 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 133)Lieferanten
- AZD2461
- 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-
- AZD 2461, >=98%
- 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
- 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
- CS-739
- AZD2461 USP/EP/BP
- 4-(4-Fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one
- AZD2461 AZD-2461
- AZD-2461, 10 mM in DMSO
- AZD2461 ，S7029
- 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one
- 1174043-16-3
- Inhibitors
- Inhibitor
