BMX-IN-1
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- CAS-Nr.
- 1431525-23-3
- Englisch Name:
- BMX-IN-1
- Synonyma:
- henyl]-;BMX-IN-1;BMX inhibitor 1;BMX-IN-1 USP/EP/BP;BMX kinase inhibitor;BMX-IN-1, 10 mM in DMSO;BMX-IN-1
(BMX kinase inhibitor;6]naphthyridin-1(2H)-yl)phenyl)acrylamide;N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1;inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1
- CBNumber:
- CB62666602
- Summenformel:
- C29H24N4O4S
- Molgewicht:
- 524.59
- MOL-Datei:
- 1431525-23-3.mol
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BMX-IN-1 Eigenschaften
- Dichte
- 1.397±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
- Aggregatzustand
- solid
- pka
- 7.77±0.10(Predicted)
- Farbe
- White to yellow
- InChIKey
- SFMJNHNUOVADRW-UHFFFAOYSA-N
- SMILES
- C(NC1=CC(N2C3=C(C=NC4=CC=C(C5=CC=C(NS(C)(=O)=O)C=C5)C=C43)C=CC2=O)=CC=C1C)(=O)C=C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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BMX-IN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC
50 = 8 nM) that targets Cys
496 in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC
50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI
50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI
50s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).
BMX-IN-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BMX-IN-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
- BMX kinase inhibitor
- N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide
- N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
- henyl]-
- BMX-IN-1
- BMX-INQ: What is
BMX-IN Q: What is the CAS Number of
BMX-IN Q: What is the storage condition of
BMX-IN
- BMX-IN-1 USP/EP/BP
- 2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-
- BMX inhibitor 1
- BMX-IN-1
(BMX kinase inhibitor
- N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1
- BMX KINASE INHIBITOR;N-(2-METHYL-5-(9-(4-(METHYLSULFONAMIDO)PHENYL)-2-OXOBENZO[H][1;6]NAPHTHYRIDIN-1(2H)-YL)PHENYL)ACRYLAMIDE
- 6]naphthyridin-1(2H)-yl)phenyl)acrylamide
- inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1
- BMX-IN-1, 10 mM in DMSO
- 1431525-23-3
