5-Ethynyl-2'-deoxycytidine

69075-47-4

CAS-Nr.: 69075-47-4

Englisch Name:: 5-Ethynyl-2'-deoxycytidine

Synonyma:: 5-Ethynyl-2'-dC;-Ethynyl-2’5-Ethynyl-2'-deoxycytidine;2'-Deoxy-5-ethynylcytidine;5'-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine>Cytidine, 2'-deoxy-5-ethynyl-;5-Ethynyl-2′-deoxycytidine, (EdC);5-Ethynyl-2'-deoxycytidine 69075-47-4;5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR

CBNumber:: CB62682226

Summenformel:: C11H13N3O4

Molgewicht:: 251.24

MOL-Datei:: 69075-47-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 70

5-Ethynyl-2'-deoxycytidine Eigenschaften

Schmelzpunkt:: 191 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1))

Siedepunkt:: 475.7±55.0 °C(Predicted)

Dichte: 1.54±0.1 g/cm3(Predicted)

storage temp.: Store at 2-8°C, protect from light, stored under nitrogen

L?slichkeit: DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

pka: 14.03±0.60(Predicted)

Aggregatzustand: powder to crystal

Farbe: White to Light yellow to Light orange

maximale Wellenl?nge (λmax): 292nm(H2O)(lit.)

InChI: 1S/C11H13N3O4/c1-2-6-4-14(11(17)13-10(6)12)9-3-7(16)8(5-15)18-9/h1,4,7-9,15-16H,3,5H2,(H2,12,13,17)/t7-,8+,9+/m0/s1

InChIKey: HMJSYXIPNSASJY-DJLDLDEBSA-N

SMILES: NC1=NC(=O)N(C=C1C#C)[C@H]2C[C@H](O)[C@@H](CO)O2

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

WGK Germany	3
HS Code	2934.99.4400
Speicherklasse	11 - Combustible Solids

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	P-Code
H302	Gesundheitssch?dlich bei Verschlucken.	Akute Toxizit?t oral	Kategorie 4	Warnung	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizit?t (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

5-Ethynyl-2'-deoxycytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

5''-Ethynyl-2''-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID₅₀ = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1'',2''-³H]deoxyuridine over [CH₃-³H]deoxythymidine in PRK cells (ID₅₀s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID₅₀s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.

Verwenden

5-Ethynyl-2’-deoxycytidine is an lower toxicity analog of 2’-deoxycytidine, a metabolic labeling probe for DNA synthesis. 5-Ethynyl-2’-deoxycytidine is most commonly used when thymidine analogs is undesirable.

5-Ethynyl-2'-deoxycytidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-Ethynyl-2'-deoxycytidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 70)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5988	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
NewCan Biotech Limited	+86-571-86912261 19975279805	sales@newcanbio.com	China	9985	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +86-18055326116	sales1@nuowei-chem.com	China	1627	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9333	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

5-Ethynyl-2′-deoxycytidine, (EdC)
Cytidine, 2'-deoxy-5-ethynyl-
2'-Deoxy-5-ethynylcytidine
5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR
5-Ethynyl-2'-deoxycytidine
5-Ethynyl-2'-dC
4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
-Ethynyl-2&rsquo
5-Ethynyl-2'-deoxycytidine>
5-Ethynyl-2'-deoxycytidine 69075-47-4
5'-Ethynyl-2'-deoxycytidine
5-Ethynyl-2''-deoxycytidine (5-EdC), DNA synthesis monitoring probe
69075-47-4
Carbohydrates & Derivatives, Heterocycles, Nucleotides, Bases & Related Reagents

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