2-(2-(1-Hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammoniumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (K
is = 1.62, 27.5, and 2.63 nM for M
1, M
2, and M
3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (K
bs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.
Chemische Eigenschaften
White Solid
Verwenden
Mydriatic;Cholinergic receptor antagonist
Allgemeine Beschreibung
Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.
Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.
Clinical Use
Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.
2-(2-(1-Hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammoniumchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
