CALCEIN-AM
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CALCEIN-AM Eigenschaften
- Schmelzpunkt:
- >250℃
- Siedepunkt:
- 982.7±65.0 °C(Predicted)
- Dichte
- 1.49±0.1 g/cm3(Predicted)
- Brechungsindex
- n
20/D 1.479
- Flammpunkt:
- 85 °C
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear, colorless to slightly yellow
- pka
- 2.66±0.50(Predicted)
- Aggregatzustand
- powder
- Farbe
- Colorless
- Aussehen
- Solid Powder
- maximale Wellenl?nge (λmax)
- < 300 nm
- Biologische Anwendungen
- Calcium indicators; zinc indicators; cytotoxicity assays; apoptosis assays; viability assays; labile iron pool assays; chemotaxis probes; cell adhesion probes; mitochondrial probes; P-glycoprotein probes;multi-drug resistance probes;treating atherosclerosis,cancer;ischemic disease
- InChIKey
- BQRGNLJZBFXNCZ-UHFFFAOYSA-N
- SMILES
- C12(C3=C(C=C(OC(C)=O)C(CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=C3)OC3=C1C=C(CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OC(C)=O)=C3)C1=C(C=CC=C1)C(=O)O2
Sicherheit
| Kennzeichnung gef?hrlicher | Xi | ||
|---|---|---|---|
| R-S?tze: | 36/37/38 | ||
| S-S?tze: | 26-36 | ||
| RIDADR | NA 1993 / PGIII | ||
| WGK Germany | 3 | ||
| F | 10-21 | ||
| Speicherklasse | 11 - Combustible Solids |
CALCEIN-AM Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
A colorless to slightly yellow solid. Soluble in dimethyl sulfoxide.Verwenden
Calcein-AM appears to best satisfy the criteria for assaying cell adhesion and to have the least effect on cell viability and cell functions.Allgemeine Beschreibung
Liposomes contain a self-quenching fluorescent dye called calcein. It is a fluorescent dye with excitation and emission wavelengths of 495/515 nm, respectively. It self-quenches at concentrations above 70mM and is commonly used as an indicator of lipid vesicle leakage. The leakage rate is calculated on the basis of the fluorescence increment as the entrapped calcein is leaked out of the liposomal compartment. It is used as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.Biochem/physiol Actions
Fluorescent cell permeable derivative of calcein.Einzelnachweise
[1] JAMES HYNES . Fluorescence-Based Cell Viability Screening Assays Using Water-Soluble Oxygen Probes[J]. SLAS Discovery, 2003, 8 3: Pages 264-272. DOI:10.1177/1087057103008003004.[2] SABNIS R W. Handbook of Biological Dyes and Stains: Synthesis and Industrial Applications[C]. 2010: 0. DOI:10.1002/9780470586242.
[3] Polli, J.W., Wring, S.A., Humphreys, J.E., et al. Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299(2), 620-628 (2001).
[4] Tiberghien, F., and Loor, F. Ranking of P-glycoprotein substates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs 7(5), 568-578 (1996).
[5] Szakács, G., Jakab, K., Antal, F., et al. Diagnostics of multidrug resistance in cancer. Pathol.Oncol.Res. 4(4), 251-257 (2016).
[6] X M WANG. A new microcellular cytotoxicity test based on calcein AM release.[J]. Human Immunology, 1993, 37 4: 264-270. DOI:10.1016/0198-8859(93)90510-8.
[7] ZSOLT HOLLó . Calcein accumulation as a fluorometric functional assay of the multidrug transporter[J]. Biochimica et biophysica acta. Biomembranes, 1994, 1191 2: Pages 384-388. DOI:10.1016/0005-2736(94)90190-2.
CALCEIN-AM Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CALCEIN-AM Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 223)Lieferanten
| Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3618 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19935 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 |
ada@ipurechemical.com | China | 10224 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 |
ada@ipurechemical.com | CHINA | 3453 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +86-13336024896 |
CB@aromsyn.com | China | 19176 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 |
mina@chuanghaibio.com | China | 18114 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 12270 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 |
masar@topule.com | China | 8433 | 58 |
148504-34-1()Verwandte Suche:
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Methylisocyanacetat
- 3',6'-Di(O-acetyl)-2',7'-bis[N,N-bis(carboxymethyl)aminomethyl]fluoresceintetraacetoxymethylester,DMSOsolution
- Calcein AM solution
- CALCEIN, AM;CAL-AM
- 4',5'-Bis(N,N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester
- Glycine, N,N'-((3',6'-bis(acetyloxy)-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-2',7'-diyl)bis(methylene))bis(N-(2-((acetyloxy)methoxy)-2-oxoethyl)-, bis((acetyloxy)methyl) ester
- N,N'-[[3',6'-Bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(Methylene)]bis[N-[2-[(acetyloxy)Methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy) Methyl] Ester
- NSC 689290
- CALCEIN-ACETOXYMETHYL ESTER, DIACETATE
- CALCEIN-AM
- CAL-AM
- 3',6'-DI(O-ACETYL)-2',7'-BIS(N,N-BIS(CARBOXYMETHYL)-AMINOMETHYL)FLUORESCEIN-TETRAACETOXYMETHYL ESTER
- Cellstain- Calcein-AM
- CALCEIN-AM SOLUTION, 1 MMOL IN DMSO*
- CALCEIN AM, 4MM IN ANHYDROUS DMSO
- -Cellstain-Calcein-AmSolution
- calcein o,o'-diacetate tetrakis(acetoxymethyl)ester
- Calcein O,o0-diacetate Tetrakis(acetoxymethyl) ester
- Glycine, N,n0-[[30,60-bis(acetyloxy)-3-oxospiro[ isobenzofuran-1(3h),90-[9h]xanthene]-20,70-diyl] bis(methylene)]bis[n-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, bis[(acetyloxy)methyl] Ester
- Calcein, AM *CAS 148504-34-1*
- Calcein, AM *UltraPure grade* *CAS 148504-34-1*
- Calcein AM (Calcein acetoxymethyl ester)
- Calcein-AM - CAS 148504-34-1 - Calbiochem
- Cellstain Calcein AM Solution(1mM/l DMSO) (3',6'-Di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethy
- Calcein-AM (3',6'-Di(O-acetyl)-2',7'-bis[N,N-bis(carboxymethyl)aminomethyl]fluoresceinTetraacetoxymethyl Ester)
- Glycine, N,N'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester
- AM /Calcein-AM
- Tetrakis(acetoxymethyl) 2,2',2'',2'''-(((3',6'-diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(methylene))bis(azanetriyl))tetraacetate
- Calcein AM, fluorescent dye for cell viability
- Calcein, AM UltraPure Grade, 5 mM solution in anhydrous DMSO - 200 μl
- Calcein, AM UltraPure Grade - 1 mg
- Calcein, AM UltraPure Grade Small Package - 20 x 50 μg
- 3',6'-Di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein, tetraacetoxymethyl ester
- Calcein AcetoxyMethyl Ester
- 148504-34-1
- C46H46N2O23
- Amines
- Aromatics
- Fluorescent Labels & Indicators
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Xanthene
- CCalcium Signaling Research Tools
- Calcium Probes
- Fluorescent
- Stains and Dyes
- Stains&Dyes, A to




