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Glutathion

Glutathione Struktur
70-18-8
CAS-Nr.
70-18-8
Bezeichnung:
Glutathion
Englisch Name:
Glutathione
Synonyma:
GSH;L-GLUTATHIONE REDUCED;REDUCED GLUTATHIONE;glutatione;Glutathion;Liposomal Glutathione;Glutathione powder;glutide;GLUTATHIONE REDUCED FORM;L-GLUTATHIONE (REDUCED FORM)
CBNumber:
CB6320803
Summenformel:
C10H17N3O6S
Molgewicht:
307.32
MOL-Datei:
70-18-8.mol

Glutathion Eigenschaften

Schmelzpunkt:
192-195 °C (dec.) (lit.)
Siedepunkt:
754.5±60.0 °C(Predicted)
alpha 
-16.5 º (c=2, H2O)
Dichte
1.4482 (rough estimate)
chüttdichte
160kg/m3
Brechungsindex
-17 ° (C=2, H2O)
storage temp. 
2-8°C
L?slichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
pka
pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
Farbe
White
PH
3 (10g/l, H2O, 20°C)
Geruch (Odor)
Odorless
Optische Rotation
-21.327 (H2O)
Wasserl?slichkeit
soluble
Merck 
14,4475
BRN 
1729812
Sequenz
H-γ-Glu-Cys-Gly-OH
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
Kosmetik-Inhaltsstoffe Funktionen
REDUCING
InChI
1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChIKey
RWSXRVCMGQZWBV-WDSKDSINSA-N
SMILES
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
LogP
-1.645 (est)
CAS Datenbank
70-18-8(CAS DataBase Reference)
EPA chemische Informationen
Glutathione (70-18-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 68-36/37/38
S-S?tze: 24/25-36/37/39-27-26
WGK Germany  2
RTECS-Nr. MC0556000
9-23
TSCA  TSCA listed
HS Code  29309070
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Glutathion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R68:Irreversibler Schaden m?glich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

Chemische Eigenschaften

White cryst. powder

Definition

ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

Allgemeine Beschreibung

Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Sicherheitsprofil

Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Synthese

Synthesis of Glutathione(GSH) occurs via a two-step ATP-requiring enzymatic process. The first step is catalyzed by glutamate-cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM). This step conjugates cysteine with glutamate, generating γ-glutamylcysteine. The second step is catalyzed by GSH synthase, which adds glycine to γ-glutamylcysteine to form γ-glutamylcysteinylglycine or GSH. GSH exerts a negative feedback inhibition on GCL.

l?uterung methode

Crystallise L-glutathione from 50% aqueous EtOH, dry it in a vacuum and

Glutathion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Glutathion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 1411)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sinoway Industrial co., ltd.
+86-0592-5800732 +86-13806035118
xie@china-sinoway.com China 1369 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953
info@konochemical.com China 1169 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 1287 58
Jinan Jianfeng Chemical Co., Ltd
+86-0531-88110457 +8615562555968
info@pharmachemm.com China 310 58
Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 +8617702909819
1713330907@QQ.com China 2639 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490
info@gihichemicals.com China 49968 58
Hebei Lutong Import and Export Co., Ltd
+8618131159658
judy@hbjbrh.com China 79 58
Guangzhou XinPeptide International Co.,Ltd
+8618134016563
admin@xtpeptide.com China 165 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81139210 +86-18192627656
1059@dideu.com China 3587 58
Shaanxi Dideu Medichem Co. Ltd
+8617392709771
1097@dideu.com China 3992 58

70-18-8(Glutathion)Verwandte Suche:


  • glutinal
  • N(N-L-.gamma.-Glutamyl-L-cysteinyl)glycine
  • n-(n-l-gamma-glutamyl-l-cysteinyl)-glycin
  • neuthion
  • panaron
  • tathion
  • tathione
  • triptide
  • L-Glutathione reduced Vetec(TM) reagent grade, >=98%
  • TWEEN 80 REAGENT GRADE
  • glutathiose
  • L-Glutathione Reduced(GSH)
  • Gamma Glu-L-Cys-Gly-OH
  • Glutathione(Reduced Form), free acid, Animal-Free
  • GLYCINE,N-(N-GAMMA-GLUTAMYL-CYSTEINYL)-
  • REDUCEDGLUTHATIONE
  • GLUTATHIONE PHARMACEUTICAL GRADE
  • L-GLUTATHIONE REDUCED ( INJECTABLE GRADE )
  • L-GLUTATHIONE REDUCED ( ORAL GRADE )
  • G1UTATHION
  • L-.GLUTATHIONE (REDUCED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE]
  • Bakezyme RX
  • GLUTAMYCYSTEINYLGLYCINE
  • GLUTATHIONE REDUCED extrapure for
  • 2-Amino-4-[[1-(carboxymethylcarbamoyl)-2-sulfanyl-ethyl]carbamoyl]butanoic acid
  • Glutathione, 98%, reduced, for analysis
  • Glutathione,98%,for analysis,reduced
  • Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
  • Glutathion,oxidation
  • L-Glutathione ,99%
  • L-GLUTATHIONE (REDUCED FORM)CRYST. RESEARCH GRADE
  • L-Glutathione reduced,γ-L-Glutamyl-L-cysteinyl-glycine, GSH
  • L-Glutathione ,99% [for analysis,reduced]
  • Glutathione Readuced
  • Glutathione (300 mg)
  • lutathione, reduced Glutathione
  • L-Glutathione, for analysis, reduced
  • (S)-2-AMino-5-(((R)-1-((carboxyMethyl)aMino)-3-Mercapto-1-oxopropan-2-yl)aMino)-5-oxopentanoic acid
  • Glutathione reduced SynonyMs 5-L-GlutaMyl-L-cysteinylglycine
  • Glutathione 5-L-Glutamyl-L-cysteinylglycine
  • glutathione,r-glutamyl cysteingl +glycine
  • γ-L-Glutamyl-L-cysteinyl-glycine
  • gamma-L-Glutamyl-L-cysteinylglycine~GSH
  • Glutathione reduced (GSH)
  • Glutathione, Reduced, Free Acid
  • GLUTATHIONE FREE ACID REDUCED FORM*CELL CULTURE TES
  • GLUTATHIONE REDUCED FORM FREE ACID
  • GLUTATHIONE FREE ACID REDUCED FORM*CRYSTALLINE
  • GLUTATHIONE REDUCED FORM FREE ACID*SIGMA ULTRA
  • Glutathione(Reduced)ForBiochemistry
  • N-(N-L-γ-Glutamyl-L-cysteinyl)glycine
  • Glutathione, reduced, for analysis, 98%
  • H-GAMMA-GLU-CYS-GLY-OH
  • GLUTAMYLCYSTEINYLGLYCINE, REDUCED
  • GLUTATHION (REDUCED)
  • GAMMA-L-GLUTAMYL-L-CYSTEINYGLYCINE
  • GAMMA-L-GLUTAMYL-L-CYSTEINYL-GLYCINE
  • GAMMA-L-GLUTAMYL-CYSTEINYL GLYCINE
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