Naftopidil dihydrochloride
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- CAS-Nr.
- 57149-07-2
- Englisch Name:
- Naftopidil dihydrochloride
- Synonyma:
- NAFTOPIDIL;kt-611;Flivas;Avishot;Naftopil;BM-15275;Naftopiil;NafTopIDi1;Nafitopidil;Naftopidil>
- CBNumber:
- CB6356910
- Summenformel:
- C24H28N2O3
- Molgewicht:
- 392.49
- MOL-Datei:
- 57149-07-2.mol
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Naftopidil dihydrochloride Eigenschaften
- Schmelzpunkt:
- 127 °C
- Siedepunkt:
- 517.2°C (rough estimate)
- Dichte
- 1.1592 (rough estimate)
- Brechungsindex
- 1.6300 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- methanol: >10 mg/mL
- Aggregatzustand
- solid
- pka
- 14.01±0.20(Predicted)
- Farbe
- white
- Merck
- 14,6356
- InChI
- InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
- InChIKey
- HRRBJVNMSRJFHQ-UHFFFAOYSA-N
- SMILES
- C12C=CC=CC1=CC=CC=2OCC(O)CN1CCN(C2C=CC=CC=2OC)CC1
- CAS Datenbank
- 57149-07-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
3077 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TL9336500 |
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| HS Code |
29335990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizit?t |
LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Naftopidil dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Naftopidil was launched in Japan for the treatment of dysuria
associated with benign prostatic hypertrophy (BPH). It can be prepared by a two
step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective
alpha-l-antagonist with a slightly higher affinity for the human prostatic than for
the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well
as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor
affinity. In experiments with rats or rabbits, Naftopidil was shown to be more
potent and selective for the urodynamic effect than the hypotensive effect.
Aromatic or aliphatic hydroxylation are the major routes of metabolism,
producing metabolites with a profile similar to the parent compound.
Chemische Eigenschaften
Off-White Solid
Verwenden
A α-1-Adrenergic receptor antagonist, antihypertensive.
Biologische Aktivit?t
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Naftopidil dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Naftopidil dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 391)Lieferanten
57149-07-2()Verwandte Suche:
Methylacrylat
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
Anisol
(Trifluormethoxy)benzol
Piperazin
Methylacetat
4,4-Bis(4-hydroxyphenyl)valeriansure
Rimantadine
Bensulfuron methyl
Anisaldehyd
2-Piperazin-1-ylethylamin
Methyl-4-hydroxybenzoat
Dimethoxydiphenylsilan
4-Methoxy-anilin
Piperazine ferulate
[2S-[2α,5α,6β(S*)]]-6-[[[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsure
Thiophanat-methyl
Kresoxim-methyl
- (+-)-1-(4-(2-methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
- 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethano
- 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol
- kt-611
- NAFTOPIDIL DIHYDROCHLORIDE (KT-611) A1 A DRENOCEPTOR ANTAG
- NafTopIDi1
- 4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride
- Naftopidil dihydrochloride
- Avishot
- Flivas
- Naftopidil Dihydrochloride See: N213501
- rac-4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride
- 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,
- 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride
- 1-Piperazineethanol, 4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]- (9CI)
- 3-[4-(2-Methoxyphenyl)piperazinyl]-1-naphthyloxypropan-2-ol
- Naftopidil and intermediates
- 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol
- (R)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol
- [R,(+)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
- (S)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol
- [S,(-)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
- 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
- 4-(2-Methoxyphenyl)-α-[(naphthalen-1-yloxy)methyl]piperazine-1-ethanol
- 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate
- 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanolhydrochloride
- rac-4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride
- 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,
- KT-611, 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrate hydrochloride
- Naftopidil hydrate hydrochloride
- Naftopidil(Flivas)
- CAS No:57149-07-2 1-Piperazineethanol,4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)Methyl]-
- Naftopiil
- Naftopil
- Naftopidil hydrochloride hydrate
- 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol dihydrochloride
- Nafitopidil
- Naftopidil dihydrochloride/Naftopidil
- BM-15275
- 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
- Naftopidil, 98%, a selective α1-adrenergic receptor antagonist
- Naftopidil>
- Naftopidil Naftopidil
- Naftopidil,>98%
- 1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-
- 4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol
- Naftopidil hydrochlo
- Naftopidil D7Q: What is
Naftopidil D7 Q: What is the CAS Number of
Naftopidil D7 Q: What is the storage condition of
Naftopidil D7 Q: What are the applications of
Naftopidil D7
- NaftopidilQ: What is
Naftopidil Q: What is the CAS Number of
Naftopidil Q: What is the storage condition of
Naftopidil Q: What are the applications of
Naftopidil
- Naftopidil, ≥ 98.0%
- Naftopidil hydrochloride, alpha1 Adrenoceptor antagonist
- Naftopidil, 10 mM in DMSO
- Naftopidil - Bio-X ?
- NAFTOPIDIL
- 57149-07-2
- 7149-07-2
- 87233-19-2
- C24H28N2O3
