BENZIMIDAVIR
|
|
|
- CAS-Nr.
- 176161-24-3
- Englisch Name:
- BENZIMIDAVIR
- Synonyma:
- Maribavir;1263W94;Maribavi;Malibawei;Malibave.;GW 257406X;BW 1263W94;BENZIMIDAVIR;Maribavir, 10 mM in DMSO;Maribavir Impurity Crystal-Free Type VI
- CBNumber:
- CB6375292
- Summenformel:
- C15H19Cl2N3O4
- Molgewicht:
- 376.24
- MOL-Datei:
- 176161-24-3.mol
|
BENZIMIDAVIR Eigenschaften
- Siedepunkt:
- 611.0±65.0 °C(Predicted)
- Dichte
- 1.67±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Powder
- pka
- 13.20±0.70(Predicted)
- Farbe
- White to off-white
- InChI
- InChI=1/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/s3
- InChIKey
- KJFBVJALEQWJBS-SIHIXHMZNA-N
- SMILES
- N1(C(NC(C)C)=NC2C=C(Cl)C(Cl)=CC1=2)[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 |&1:15,16,18,20,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
BENZIMIDAVIR Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Treatment of cytomegalovirus infections
(antiviral).
Indications
Maribavir is used to treat cytomegalovirus (CMV) infection or disease in adults and pediatric patients 12 years and older weighing at least 35 kg who have undergone transplantation and are resistant or refractory to conventional therapy (including ganciclovir, valganciclovir, cidofovir, or fomaliclovir).
Synthese
Maribavir is synthesized from 4,5-dichloro-1,2-phenylenediamine through a series of chemical reactions. The specific reaction route is as follows:
4,5-dichloro-1,2-phenylenediamine (4.1) reacts with isopropyl isothiocyanate in pyridine and generates benzimidazole (4.2) in the presence of desulfurization agent N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl p-toluenesulfonate (Morpho-CDI) with a yield of 72%. Then, this benzimidazole is coupled with 1,2,3,5-tetra-O-acetyl-β-L-ribofuranoside (4.3) under Vorbrüggen conditions (N,O-bis(trimethylsilyl)acetamide, trimethylsilane trifluoromethanesulfonate) to generate ribofuranoside (4.4) with a yield of 80-90%. Due to the participation of the ortho-O-acetyl group, the synthesis process follows Baker’s 1,2-cis rule, thus forming the target isomer. It is worth noting that the non-natural L-sugar configuration significantly affects the anti-CMV mechanism of the drug and significantly improves the pharmacokinetic properties of the drug. Finally, Maribavir (4) was obtained by deacetylation using sodium carbonate in an ethanol/water mixed solvent with a yield of 85-90%.
BENZIMIDAVIR Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BENZIMIDAVIR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 186)Lieferanten
176161-24-3()Verwandte Suche:
- 5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine
- BW 1263W94
- GW 257406X
- (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)t
- 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE
- BENZIMIDAVIR
- BENZIMIDAVIR, 5,6-DICHLORO-2-（ISOPROPYLAMINO）-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
- 5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
- BENZIMIDAVIR: 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(SS-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
- (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetr
- 1263W94
- 1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-
- Maribavi
- Malibawei
- Malibave.
- Maribavir Impurity Crystal-Free Type VI
- Maribavir, 10 mM in DMSO
- Maribavir
- 176161-24-3
- 76161-24-3
- C15H19Cl2N3O4
- Inhibitors
