SJA6017

190274-53-4

CAS-Nr.: 190274-53-4

Englisch Name:: SJA6017

Synonyma:: SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-

CBNumber:: CB6427018

Summenformel:: C17H25FN2O4S

Molgewicht:: 372.45

MOL-Datei:: 190274-53-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 50

SJA6017 Eigenschaften

Dichte: 1.185±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

L?slichkeit: DMSO: 5 mg/ml

Aggregatzustand: A lyophilized solid

pka: 9.04±0.50(Predicted)

Farbe: white

InChI: 1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)

InChIKey: WSJWUIDLGZAXID-UHFFFAOYSA-N

SMILES: Fc1ccc(cc1)[S](=O)(=O)NC(C(C)C)C(=O)NC(CC(C)C)C=O

Sicherheit

WGK Germany	WGK 1
Speicherklasse	11 - Combustible Solids

SJA6017 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC₅₀ = 7.5 nM) and m-calpain (calpain-2; IC₅₀ = 78 nM). It also inhibits cathepsins B and L (IC₅₀s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

SJA6017 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SJA6017 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19853	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Nanjing TGpeptide	+86-13347807150	support@tgpeptide.com	China	3279	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42934	64

N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL
4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE
4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL
CALPAIN INHIBITOR VI
SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
SJA6017
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
Calpain Inhibitor 4
Calpain-In-4
Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
190274-53-4

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